Gene Symbol | CYB5R3 |
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Entrez Gene | 1727 |
Alt Symbol | B5R, DIA1 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome b5 reductase 3 |
Other Description | NADH-cytochrome b5 reductase 3|NADH-cytochrome b5 reductase 3 membrane-bound form|NADH-cytochrome b5 reductase 3 soluble form|diaphorase-1 |
Swissprots | O75675 Q8TDL8 B1AHF2 Q9UEN5 B7Z7L3 Q9UL56 Q8WTS8 Q9UEN4 Q9UL55 P00387 |
Accessions | AAA59900 AAB35212 AAF06818 AAF06819 AAP88936 EAW73268 EAW73269 EAW73270 EAW73271 EAW73272 EAW73273 P00387 AF361370 AAL87744 AJ010116 CAA09006 AJ010117 CAA09007 AJ010118 CAA09008 AJ310899 CAC84523 AJ310900 CAC84524 AK124528 BAC85875 AK302204 BAH13649 AY421733 AAR38507 AY421734 AAR38508 AY421735 AAR38509 BC004821 AAH04821 BM564146 BP425383 BT009821 AAP88823 BX334220 BX366240 CB118906 CR456435 CAG30321 CU012995 CAK54426 CU013283 CAK54725 DA268749 DA548643 DA966919 DB029897 M16461 AAA52306 M16462 AAA52307 Y09501 CAA70696 NM_000398 NP_000389 NM_001129819 NP_001123291 NM_001171660 NP_001165131 NM_001171661 NP_001165132 NM_007326 NP_015565 |
Function | Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. |
Subcellular Location | Isoform 1: Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side. Mitochondrion outer membrane; Lipid-anchor; Cytoplasmic side. |
Tissue Specificity | Isoform 2 is expressed at late stages of erythroid maturation. |
Top Pathways | Amino sugar and nucleotide sugar metabolism |
CYB5R3 CRISPR/Cas9 KO Plasmid (h) - sc-404764 from Santa Cruz Biotechnology
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CYB5R3 HDR Plasmid (h) - sc-404764-HDR from Santa Cruz Biotechnology
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CYB5R3 Double Nickase Plasmid (h) - sc-404764-NIC from Santa Cruz Biotechnology
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CYB5R3 Double Nickase Plasmid (h2) - sc-404764-NIC-2 from Santa Cruz Biotechnology
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CYB5R3 CRISPR Activation Plasmid (h) - sc-404764-ACT from Santa Cruz Biotechnology
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CYB5R3 CRISPR Activation Plasmid (h2) - sc-404764-ACT-2 from Santa Cruz Biotechnology
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CYB5R3 Lentiviral Activation Particles (h) - sc-404764-LAC from Santa Cruz Biotechnology
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CYB5R3 Lentiviral Activation Particles (h2) - sc-404764-LAC-2 from Santa Cruz Biotechnology
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CYB5R3 siRNA (h) - sc-62173 from Santa Cruz Biotechnology
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CYB5R3 shRNA Plasmid (h) - sc-62173-SH from Santa Cruz Biotechnology
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CYB5R3 shRNA (h) Lentiviral Particles - sc-62173-V from Santa Cruz Biotechnology
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CYB5R3 RNAi - H00001727-R01 from Novus Biologicals
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CYB5R3 RNAi - H00001727-R02 from Novus Biologicals
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MISSION® esiRNA - EHU123781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6852 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6852 from Sigma-Aldrich
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CYB5R3 siRNA (Human) - CRH1196 from Cohesion Biosciences
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CYB5R3 - MBS8210359 from MyBioSource
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shRNA set against Human CYB5R3 (NM_007326.4) - SHH272605 from Creative biogene
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Human CYB5R3 siRNA - orb261698 from Biorbyt
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CYB5R3 shRNA Plasmid (Human) - CHH1196 from Cohesion Biosciences
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CYB5R3 miRNA 3'UTR clone - MiUTR3H-12787 from Creative biogene
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CYB5R3 miRNA 3'UTR clone - MiUTR3H-12788 from Creative biogene
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CYB5R3 miRNA 3'UTR clone - MiUTR3H-12789 from Creative biogene
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