| Gene Symbol |
RARB
|
| Entrez Gene |
5915
|
| Alt Symbol |
HAP, MCOPS12, NR1B2, RRB2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoic acid receptor, beta
|
| Other Description |
HBV-activated protein|RAR-beta|RAR-epsilon|hepatitis B virus activated protein|nuclear receptor subfamily 1 group B member 2|retinoic acid receptor beta|retinoic acid receptor, beta polypeptide
|
| Swissprots |
Q9UN48 Q00989 P10826 Q15298 P12891
|
| Accessions |
AAA58728 CAA27637 CAA54740 CAM91170 EAW64354 EAW64355 P10826 AB307688 BAH02279 AF157483 AAD45688 AK292032 BAF84721 AK299756 BAG61645 AY501390 AAS85757 BC030234 BC050415 AAH50415 BC060794 AAH60794 BC069735 AAH69735 CD014020 CD014021 CD014022 CR536558 CAG38795 DA882771 DC376623 DQ083391 AAZ32403 HQ692863 ADZ17374 HQ692864 ADZ17375 M62303 AAA60264 S82362 X07282 CAA30262 Y00291 CAA68398 NM_000965 NP_000956 NM_001290216 NP_001277145 NM_001290217 NP_001277146 NM_001290266 NP_001277195 NM_001290276 NP_001277205 NM_001290277 NP_001277206 NM_001290300 NP_001277229 NM_016152 NP_057236 NR_110892 NR_110893
|
| Function |
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. {ECO:0000269|PubMed:12554770}.
|
| Subcellular Location |
Isoform Beta-4: Cytoplasm.
|
| Top Pathways |
Small cell lung cancer, Non-small cell lung cancer
|
![Western Blot: Retinoic Acid Receptor beta Overexpression Lysate (Adult Normal) [NBL1-15157] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Retinoic Acid Receptor beta.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3325_Retinoic%2520Acid%2520Receptor%2520beta%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15157-img0002.jpg)