CHEK2
| Gene Symbol | CHEK2 |
|---|---|
| Entrez Gene | 11200 |
| Alt Symbol | CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | checkpoint kinase 2 |
| Other Description | CHK2 checkpoint homolog|cds1 homolog|checkpoint-like protein CHK2|serine/threonine-protein kinase Chk2 |
| Swissprots | Q9UGF1 Q6QA07 Q6QA08 Q6QA06 Q6QA10 Q9HCQ8 Q6QA12 B7ZBF5 Q6QA05 B7ZBF4 Q9HBS5 B7ZBF3 A8K3Y9 Q9UGF0 O96017 Q6QA03 Q6QA13 Q6QA04 Q6QA11 |
| Accessions | AAV41895 EAW59754 EAW59755 EAW59756 EAW59757 O96017 AB040105 BAB17231 AB164374 AF086904 AAC83693 AF096279 AAD11784 AF174135 AAD48504 AF217975 AAG17218 AJ131197 CAA10319 AJ783839 CAH04270 AK289360 BAF82049 AK290754 BAF83443 AW778747 AY551295 AAS58456 AY551296 AAS58457 AY551297 AAS58458 AY551298 AAS58459 AY551299 AAS58460 AY551300 AAS58461 AY551301 AAS58462 AY551302 AAS58463 AY551303 AAS58464 AY551304 AAS58465 AY551305 AAS58466 BC004207 AAH04207 BM838597 CR456418 CAG30304 CU012979 CAK54410 CU013267 CAK54709 DQ893133 ABM84059 DQ896413 ABM87412 XM_006724114 XP_006724177 XM_006724116 XP_006724179 XM_011529839 XP_011528141 XM_011529840 XP_011528142 XM_011529841 XP_011528143 XM_011529842 XP_011528144 XM_011529843 XP_011528145 XM_011529844 XP_011528146 XM_011529845 XP_011528147 XR_937805 XR_937806 XR_937807 NM_001005735 NP_001005735 NM_001257387 NP_001244316 NM_007194 NP_009125 NM_145862 NP_665861 |
| Function | Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X- R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphor |
| Subcellular Location | Isoform 12: Nucleus. |
| Tissue Specificity | High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues. |
| Top Pathways | Cell cycle, p53 signaling pathway, HTLV-I infection |
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