| Gene Symbol | CAMK1D |
|---|---|
| Entrez Gene | 57118 |
| Alt Symbol | CKLiK, CaM-K1, CaMKID |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent protein kinase ID |
| Other Description | CaM kinase ID|CamKI-like protein kinase|caM kinase I delta|caM-KI delta|caMKI delta|calcium/calmodulin-dependent protein kinase type 1D |
| Swissprots | B0YIY0 Q8IU85 Q9HD31 |
| Accessions | ACA05958 ACA05959 ACA05960 CBX51344 EAW86314 EAW86315 EAW86316 Q8IU85 AA601559 AA903749 AB081726 BAC19846 AF286366 AAG00534 AI821714 AK097377 AK289393 BAF82082 AV760219 BC035745 AAH35745 BC073155 BM930742 BQ059621 BU542765 DB114811 DQ892464 ABM83390 DQ895676 ABM86602 HY168807 XM_006717481 XP_006717544 XM_006717482 XP_006717545 XM_006717483 XP_006717546 XM_011519591 XP_011517893 XM_011519592 XP_011517894 XM_011519593 XP_011517895 XM_011519594 XP_011517896 XM_011519595 XP_011517897 XM_011519596 XP_011517898 NM_020397 NP_065130 NM_153498 NP_705718 NR_027322 |
| Function | Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine- induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}. |
| Subcellular Location | Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons. |
| Tissue Specificity | Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:12935886, ECO:0000269|PubMed:15840691}. |
| Top Pathways | Oxytocin signaling pathway |