| Gene Symbol |
NCAPG
|
| Entrez Gene |
64151
|
| Alt Symbol |
CAPG, CHCG, NY-MEL-3, YCG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
non-SMC condensin I complex, subunit G
|
| Other Description |
XCAP-G homolog|chromosome condensation protein G|chromosome-associated protein G|condensin complex subunit 3|condensin subunit CAP-G|melanoma antigen NY-MEL-3
|
| Swissprots |
Q9BUR3 Q9BVY1 Q9H914 Q3MJE0 Q96SV9 Q9BPX3 Q9H9Z6 Q9HBI9
|
| Accessions |
EAW92785 Q9BPX3 AB013299 BAB21557 AF235023 AAG30732 AF331796 AAG49627 AK022512 BAB14069 AK023147 BAB14429 AK027511 BAB55165 BC000827 AAH00827 BC002337 BC068467 AAH68467 BC101476 AAI01477 BC143383 BG398543 BM743260 BX474610 DB451361 XM_011513876 XP_011512178 XM_011513877 XP_011512179 XR_925347 NM_022346 NP_071741 NR_073124
|
| Function |
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
|
| Tissue Specificity |
Highly expressed in testis. {ECO:0000269|PubMed:10910072}.
|