| Gene Symbol |
Arap1
|
| Entrez Gene |
69710
|
| Alt Symbol |
2410002L19Rik, Centd2, mKIAA0782
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
|
| Other Description |
arap1|arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1|centaurin, delta 2|centaurin-delta-2|cnt-d2
|
| Swissprots |
Q6ZQ48 Q6PEQ9 Q3US99 Q3UDD2 Q58ET6 B2RUJ3 Q4LDD4
|
| Accessions |
EDL16507 EDL16508 EDL16509 EDL16510 EDL16511 Q4LDD4 AJ621558 CAF21318 AK010344 BAB26867 AK052437 AK129213 BAC98023 AK137455 BAE23358 AK140646 BAE24434 AK150132 BAE29329 AK172210 AK199434 AK210757 BC042640 BC057922 AAH57922 BC069849 BC083088 BC091762 AAH91762 BC141179 AAI41180 BY067725 BY120456 BY130843 BY201659 BY210574 BY211609 BY231799 BY317143 XM_006508186 XP_006508249 XM_006508187 XP_006508250 XM_006508188 XP_006508251 XM_006508189 XP_006508252 XM_006508190 XP_006508253 XM_006508191 XP_006508254 XM_006508192 XP_006508255 XM_006508193 XP_006508256 XM_006508195 XP_006508258 XM_006508196 XP_006508259 XM_011241897 XP_011240199 XR_869744 NM_001040111 NP_001035200 NM_001040112 NP_001035201 NM_027180 NP_081456 NM_198096 NP_932764
|
| Function |
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250|UniProtKB:Q96P48}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q96P48}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96P48}. Cell membrane {ECO:0000250|UniProtKB:Q96P48}.
|
| Top Pathways |
Endocytosis
|