| Gene Symbol | PGLYRP4 |
|---|---|
| Entrez Gene | 57115 |
| Alt Symbol | PGLYRPIbeta, PGRP-Ibeta, PGRPIB, SBBI67 |
| Species | Human |
| Gene Type | protein-coding |
| Description | peptidoglycan recognition protein 4 |
| Other Description | PGRP-I-beta|peptidoglycan recognition protein I beta|peptidoglycan recognition protein I-beta|peptidoglycan recognition protein intermediate beta|peptidoglycan recognition protein-I-beta |
| Swissprots | Q5SY64 Q3B823 Q5SY63 A8K838 Q96LB8 Q3B822 Q9HD75 |
| Accessions | EAW53335 EAW53336 EAW53337 Q96LB8 AF086392 AF242518 AAF99599 AK292203 BAF84892 AY035377 AAK72485 BC107157 AAI07158 BC107158 AAI07159 BC142636 AAI42637 CA487280 XM_011509789 XP_011508091 XM_011509790 XP_011508092 XM_011509791 XP_011508093 XM_011509792 XP_011508094 XM_011509793 XP_011508095 XR_921896 XR_921897 NM_020393 NP_065126 |
| Function | Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:16354652}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:16354652}. |
| Tissue Specificity | Detected in skin epidermis, eccrine sweat glands and ducts, mucous cells in the submandibular salivary gland, mucous cells in the throat, ciliary body epithelial cells of the eye, small intestine, colon, stomach and in mature epithelial cells of the tongue (at protein level). High expression in skin and esophagus. Expressed also to a much lesser extent in the tonsils and thymus. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:16354652}. |