| Gene Symbol |
MAZ
|
| Entrez Gene |
4150
|
| Alt Symbol |
PUR1, Pur-1, SAF-1, SAF-2, SAF-3, ZF87, ZNF801, Zif87
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MYC-associated zinc finger protein (purine-binding transcription factor)
|
| Other Description |
MAZI|myc-associated zinc finger protein|purine-binding transcription factor|serum amyloid A activating factor 1|serum amyloid A activating factor 2|serum amyloid A-activating factor-1|transcription factor Zif87|zinc finger protein 801|zinc-finger protein, 87 kilodaltons
|
| Swissprots |
G5E927 P56270 Q15703 A8QJL9 H3BQD6 Q8NFN7 C6G496 Q99443
|
| Accessions |
AAC08710 BAA33064 EAW79994 EAW79995 EAW79996 EAW79997 EAW79998 EAW79999 EAW80000 EAW80001 EAW80002 EAW80003 P56270 AA588396 AB209061 BAD92298 AF489858 AAN03800 AI079560 AI360548 AK074720 BC039057 BC041629 AAH41629 BI198991 BM695402 BQ431307 BU615653 BX362240 BX363391 CN483327 D85131 BAA12728 EF059746 ABN80996 FJ532357 ACS26236 HY067550 HY087969 L01420 AAL31317 M93339 M94046 U33819 AAB04121 XM_006721047 XP_006721110 XM_006721048 XP_006721111 NM_001042539 NP_001036004 NM_001276275 NP_001263204 NM_001276276 NP_001263205 NM_002383 NP_002374 NR_074080
|
| Function |
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins. {ECO:0000269|PubMed:12270922}.
|
| Subcellular Location |
Nucleus {ECO:0000305|PubMed:10727212}. Note=In brains of Alzheimer disease patients, present in a plaque- like structures.
|
| Tissue Specificity |
Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level). {ECO:0000269|PubMed:10727212}.
|