| Gene Symbol | PSMB8 |
|---|---|
| Entrez Gene | 5696 |
| Alt Symbol | ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PSMB5i, RING10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | proteasome (prosome, macropain) subunit, beta type, 8 |
| Other Description | large multifunctional peptidase 7|low molecular mass protein 7|low molecular weight protein 7|macropain subunit C13|multicatalytic endopeptidase complex subunit C13|protease component C13|proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)|proteasome catalytic subunit 3i|proteasome component C13|proteasome subunit Y2|proteasome subunit beta 5i|proteasome subunit beta type-8|proteasome-related gene 7|really interesting new gene 10 protein |
| Swissprots | Q96J48 B0UZC0 Q29824 Q5QNR8 Q5JNW6 P28062 |
| Accessions | AAA80234 AAA80235 AHW47925 AHW47942 AHW47959 AHW47976 CAA47026 CAA60786 CAA60787 CAA78705 CAA78706 EAX03644 EAX03645 P28062 AA807046 AK300962 BAH13383 AW242683 BC001114 AAH01114 BG547344 BG760674 BM547457 BM781620 CR541661 CAG46462 U17496 AAA56777 U17497 AAA56778 X62598 CAA44482 NM_004159 NP_004150 NM_148919 NP_683720 |
| Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. {ECO:0000269|PubMed:16423992, ECO:0000269|PubMed:19443843, ECO:0000269|PubMed:21881205, ECO:0000269|PubMed:8163024}. |
| Subcellular Location | Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}. |
| Top Pathways | Proteasome |