PSMB8

Gene Symbol	PSMB8
Entrez Gene	5696
Alt Symbol	ALDD, D6S216, D6S216E, JMP, LMP7, NKJO, PSMB5i, RING10
Species	Human
Gene Type	protein-coding
Description	proteasome (prosome, macropain) subunit, beta type, 8
Other Description	large multifunctional peptidase 7|low molecular mass protein 7|low molecular weight protein 7|macropain subunit C13|multicatalytic endopeptidase complex subunit C13|protease component C13|proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)|proteasome catalytic subunit 3i|proteasome component C13|proteasome subunit Y2|proteasome subunit beta 5i|proteasome subunit beta type-8|proteasome-related gene 7|really interesting new gene 10 protein
Swissprots	Q96J48 B0UZC0 Q29824 Q5QNR8 Q5JNW6 P28062
Accessions	AAA80234 AAA80235 AHW47925 AHW47942 AHW47959 AHW47976 CAA47026 CAA60786 CAA60787 CAA78705 CAA78706 EAX03644 EAX03645 P28062 AA807046 AK300962 BAH13383 AW242683 BC001114 AAH01114 BG547344 BG760674 BM547457 BM781620 CR541661 CAG46462 U17496 AAA56777 U17497 AAA56778 X62598 CAA44482 NM_004159 NP_004150 NM_148919 NP_683720
Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. {ECO:0000269|PubMed:16423992, ECO:0000269|PubMed:19443843, ECO:0000269|PubMed:21881205, ECO:0000269|PubMed:8163024}.
Subcellular Location	Cytoplasm {ECO:0000255|PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}.
Top Pathways	Proteasome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Proteasome 20S LMP7 full length protein - ab131998 from Abcam Category Protein Source Wheat germ Species Human

Human Proteasome 20S LMP7 full length protein - ab137150 from Abcam Category Protein Source E. coli Species Human

Human Proteasome 20S LMP7 peptide - ab4945 from Abcam Category Peptide Species Human

Human Proteasome 20S LMP7 peptide - ab91637 from Abcam Category Peptide Species Human

PSMB8 / LMP7 Antibody Blocking Peptide - LS-E3401 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PSMB8 / LMP7 Antibody Blocking Peptide - LS-E27091 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LMP7/PSMB8 Partial Recombinant Protein - H00005696-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human LMP7/PSMB8 Protein - H00005696-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human LMP7/PSMB8 Protein - NBP2-23374 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

PSMB8-Antibody-N-term-Blocking-Peptide - BP14577a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PSMB8 blocking peptide - GTX88410-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

Human PSMB8 protein - orb169100 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Goat anti PSMB8 antibody Immunizing peptide - orb15630 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PSMB8 protein (His tag) - 80R-2608 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Human LMP7 Protein - abx067714 from Abbexa Category Protein Source E.coli Species Human

Proteasome 20S LMP7 Peptide - AC21-1913-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PSMB8 (73-276, His-tag) - AR50654PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PSMB8 (73-276, His-tag) - AR50654PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PSMB8 - H00005696-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PSMB8 - H00005696-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PSMB8 - H00005696-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PSMB8 - H00005696-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PSMB8 control peptide - SP5376CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Large Multifunctional Peptidase 7 (LMP7), Human - 20-9648 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

PSMB8, 73-276aa, Human, His tag, E.coli - 01-P1830 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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