| Gene Symbol | Vamp7 |
|---|---|
| Entrez Gene | 20955 |
| Alt Symbol | Sybl1, TI-VAMP, VAMP-7 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | vesicle-associated membrane protein 7 |
| Other Description | synaptobrevin like 1|synaptobrevin-like protein 1|tetanus neurotoxin-insensitive vesicle-associated membrane protein |
| Swissprots | P70280 |
| Accessions | CAB94231 EDL07807 EDL07808 EDL07809 P70280 AK002825 BAB22386 AK005487 BAB24073 AK011510 BAB27667 AK083293 AK089035 BAC40712 AK165299 BAE38126 BC003764 AAH03764 BP768744 X96737 CAA65509 XM_006535856 XP_006535919 XM_011249809 XP_011248111 NM_001302138 NP_001289067 NM_011515 NP_035645 |
| Function | Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. {ECO:0000269|PubMed:15470500}. |
| Subcellular Location | Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type IV membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Late endosome membrane; Single- pass type IV membrane protein. Lysosome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity). {ECO:0000250}. |
| Top Pathways | SNARE interactions in vesicular transport |
TI-VAMP CRISPR/Cas9 KO Plasmid (m) - sc-423230 from Santa Cruz Biotechnology
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TI-VAMP HDR Plasmid (m) - sc-423230-HDR from Santa Cruz Biotechnology
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TI-VAMP Double Nickase Plasmid (m) - sc-423230-NIC from Santa Cruz Biotechnology
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TI-VAMP Double Nickase Plasmid (m2) - sc-423230-NIC-2 from Santa Cruz Biotechnology
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TI-VAMP CRISPR Activation Plasmid (m) - sc-423230-ACT from Santa Cruz Biotechnology
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TI-VAMP CRISPR Activation Plasmid (m2) - sc-423230-ACT-2 from Santa Cruz Biotechnology
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TI-VAMP Lentiviral Activation Particles (m) - sc-423230-LAC from Santa Cruz Biotechnology
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TI-VAMP Lentiviral Activation Particles (m2) - sc-423230-LAC-2 from Santa Cruz Biotechnology
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TI-VAMP siRNA (m) - sc-44607 from Santa Cruz Biotechnology
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TI-VAMP shRNA Plasmid (m) - sc-44607-SH from Santa Cruz Biotechnology
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TI-VAMP shRNA (m) Lentiviral Particles - sc-44607-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU084691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN44074 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44074 from Sigma-Aldrich
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VAMP7 siRNA (Mouse) - CRM3984 from Cohesion Biosciences
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VAMP7 - MBS8216183 from MyBioSource
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shRNA set against Mouse Vamp7 (NM_011515.4) - SHH442192 from Creative biogene
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VAMP7 shRNA Plasmid (Mouse) - CHM3984 from Cohesion Biosciences
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VAMP7 miRNA 3'UTR clone - MiUTR1M-11423 from Creative biogene
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