Gene Symbol | MEX3B |
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Entrez Gene | 84206 |
Alt Symbol | MEX-3B, RKHD3, RNF195 |
Species | Human |
Gene Type | protein-coding |
Description | mex-3 RNA binding family member B |
Other Description | RING finger protein 195|RNA-binding protein MEX3B|ring finger and KH domain containing 3 |
Swissprots | Q9H0J0 Q6ZN04 Q8IVG2 Q4G0W1 |
Accessions | EAW99090 Q6ZN04 AA442153 AB095929 BAC23105 AK094145 AK094633 AK131424 BAD18571 AL136778 CAB66712 AM393015 CAL37893 AM393799 CAL38674 AY950678 AAY34146 BC036211 AAH36211 BC111545 AAI11546 HY013949 NM_032246 NP_115622 |
Function | RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:18779327}. Cytoplasm {ECO:0000269|PubMed:18779327}. Cytoplasm, P-body {ECO:0000269|PubMed:18779327}. Cytoplasmic granule {ECO:0000269|PubMed:18779327}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3. |
Tissue Specificity | Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level. {ECO:0000269|PubMed:17267406}. |
Mex3b CRISPR/Cas9 KO Plasmid (h) - sc-405164 from Santa Cruz Biotechnology
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Mex3b HDR Plasmid (h) - sc-405164-HDR from Santa Cruz Biotechnology
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Mex3b Double Nickase Plasmid (h) - sc-405164-NIC from Santa Cruz Biotechnology
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Mex3b Double Nickase Plasmid (h2) - sc-405164-NIC-2 from Santa Cruz Biotechnology
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Mex3b CRISPR Activation Plasmid (h) - sc-405164-ACT from Santa Cruz Biotechnology
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Mex3b CRISPR Activation Plasmid (h2) - sc-405164-ACT-2 from Santa Cruz Biotechnology
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Mex3b Lentiviral Activation Particles (h) - sc-405164-LAC from Santa Cruz Biotechnology
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Mex3b Lentiviral Activation Particles (h2) - sc-405164-LAC-2 from Santa Cruz Biotechnology
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Mex3b siRNA (h) - sc-90269 from Santa Cruz Biotechnology
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Mex3b shRNA Plasmid (h) - sc-90269-SH from Santa Cruz Biotechnology
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Mex3b shRNA (h) Lentiviral Particles - sc-90269-V from Santa Cruz Biotechnology
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RKHD3 RNAi - H00084206-R03 from Novus Biologicals
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MISSION® esiRNA - EHU154531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13242 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13242 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09740 from Sigma-Aldrich
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MEX3B siRNA (Human) - CRJ3351 from Cohesion Biosciences
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shRNA set against Human MEX3B (NM_032246.4) - SHH340935 from Creative biogene
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MEX3B shRNA Plasmid (Human) - CHJ3351 from Cohesion Biosciences
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MEX3B miRNA 3'UTR clone - MiUTR3H-11609 from Creative biogene
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