Gene Symbol | MEAF6 |
---|---|
Entrez Gene | 64769 |
Alt Symbol | C1orf149, CENP-28, EAF6, NY-SAR-91 |
Species | Human |
Gene Type | protein-coding |
Description | MYST/Esa1-associated factor 6 |
Other Description | Esa1p-associated factor 6 homolog|centromere protein 28|chromatin modification-related protein MEAF6|protein EAF6 homolog|sarcoma antigen NY-SAR-91 |
Swissprots | Q4F967 B1AK64 Q86WE3 Q9HAF1 Q7Z311 |
Accessions | EAX07339 EAX07340 EAX07341 EAX07342 EAX07343 EAX07344 Q9HAF1 AK021792 BAB13898 AK225434 AK225598 AK308118 AK309663 AY007166 AY211926 AAO65179 BC016328 AAH16328 BC043239 BC056406 AAH56406 BM840891 BX386498 BX538212 CAD98071 BX640719 CAE45838 DQ099384 AAZ13760 EU831681 ACE86515 EU832519 ACE87691 EU832600 ACE87002 HQ448659 ADQ33137 XR_946741 NM_001270875 NP_001257804 NM_001270876 NP_001257805 NM_022756 NP_073593 NR_073090 NR_073091 NR_073092 |
Function | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:18794358}. |