| Gene Symbol |
ADAM10
|
| Entrez Gene |
282132
|
| Alt Symbol |
ADAM 10
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
ADAM metallopeptidase domain 10
|
| Other Description |
disintegrin and metalloproteinase domain-containing protein 10|kuzbanian protein homolog|mammalian disintegrin-metalloprotease|myelin-associated metalloproteinase
|
| Swissprots |
Q10741 A8E663
|
| Accessions |
DAA25313 Q10741 BC153863 AAI53864 Z21961 CAA79973 NM_174496 NP_776921
|
| Function |
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=The protealytically activated form is localized mainly in the plasma membrane whereas the proenzyme is found intracellularly in the Golgi.
|
| Tissue Specificity |
Expressed at low level in kidney, spleen, lung, adrenal, heart and peripheral nerve.
|
| Top Pathways |
Alzheimer's disease
|