| Gene Symbol |
Znrf1
|
| Entrez Gene |
170737
|
| Alt Symbol |
B830022L21Rik, Rnf42, Zrfp1, nin283
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
zinc and ring finger 1
|
| Other Description |
E3 ubiquitin-protein ligase ZNRF1|nerve injury-induced gene 283 protein|peripheral nerve injury protein nin283|ring finger protein 42|zinc ring finger protein 1|zinc/RING finger protein 1
|
| Swissprots |
Q8C5D7 Q91V17
|
| Accessions |
CAF06460 EDL11501 EDL11502 EDL11503 Q91V17 AF378525 AAK69754 AK030575 BAC27028 AK076756 BAC36468 AK078819 BAC37410 AK079338 BAC37612 AK181114 AK189177 AK191998 AK216619 BC006765 AAH06765 BC086770 AAH86770 BM950431 XM_006530731 XP_006530794 XM_006530733 XP_006530796 XM_011248320 XP_011246622 XM_011248321 XP_011246623 XM_011248322 XP_011246624 NM_001168621 NP_001162092 NM_001168622 NP_001162093 NM_001168623 NP_001162094 NM_133206 NP_573469
|
| Function |
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1- mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. {ECO:0000269|PubMed:20107048, ECO:0000269|PubMed:22057101}.
|
| Subcellular Location |
Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with synaptic vesicle membranes in neurons.
|