Gene Symbol | ALAD |
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Entrez Gene | 210 |
Alt Symbol | ALADH, PBGS |
Species | Human |
Gene Type | protein-coding |
Description | aminolevulinate dehydratase |
Other Description | aminolevulinate, delta-, dehydratase|delta-aminolevulinic acid dehydratase|porphobilinogen synthase |
Swissprots | A8K375 Q9BVQ9 Q16870 P13716 B2R6F2 Q16871 |
Accessions | AAP72012 CAA45796 EAW87379 EAW87380 P13716 AA593706 AK131490 BAD18635 AK290490 BAF83179 AK295945 BAH12225 AK312552 BAG35449 AU279870 BC000977 AAH00977 BU625796 BX494400 DA412142 DA805310 M13928 AAA51687 S99468 AAC60581 S99471 AAC60582 XM_005251799 XP_005251856 XM_011518363 XP_011516665 XM_011518364 XP_011516666 NM_000031 NP_000022 NM_001003945 |
Function | Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. {ECO:0000269|PubMed:11032836, ECO:0000269|PubMed:19812033}. |
Top Pathways | Porphyrin and chlorophyll metabolism |
PBGS CRISPR/Cas9 KO Plasmid (h) - sc-407260 from Santa Cruz Biotechnology
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PBGS HDR Plasmid (h) - sc-407260-HDR from Santa Cruz Biotechnology
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PBGS Double Nickase Plasmid (h) - sc-407260-NIC from Santa Cruz Biotechnology
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PBGS Double Nickase Plasmid (h2) - sc-407260-NIC-2 from Santa Cruz Biotechnology
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PBGS CRISPR Activation Plasmid (h) - sc-407260-ACT from Santa Cruz Biotechnology
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PBGS CRISPR Activation Plasmid (h2) - sc-407260-ACT-2 from Santa Cruz Biotechnology
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PBGS Lentiviral Activation Particles (h) - sc-407260-LAC from Santa Cruz Biotechnology
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PBGS Lentiviral Activation Particles (h2) - sc-407260-LAC-2 from Santa Cruz Biotechnology
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PBGS siRNA (h) - sc-61385 from Santa Cruz Biotechnology
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PBGS shRNA Plasmid (h) - sc-61385-SH from Santa Cruz Biotechnology
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PBGS shRNA (h) Lentiviral Particles - sc-61385-V from Santa Cruz Biotechnology
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ALAD RNAi - H00000210-R01 from Novus Biologicals
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ALAD RNAi - H00000210-R02 from Novus Biologicals
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MISSION® esiRNA - EHU150021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3038 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3038 from Sigma-Aldrich
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ALAD siRNA (Human) - CRH0145 from Cohesion Biosciences
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ALAD - MBS8217021 from MyBioSource
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shRNA set against Human ALAD (NM_000031.5) - SHH234706 from Creative biogene
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ALAD shRNA Plasmid (Human) - CHH0145 from Cohesion Biosciences
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