NOX4
| Gene Symbol | NOX4 |
|---|---|
| Entrez Gene | 50507 |
| Alt Symbol | KOX, KOX-1, RENOX |
| Species | Human |
| Gene Type | protein-coding |
| Description | NADPH oxidase 4 |
| Other Description | kidney oxidase-1|kidney superoxide-producing NADPH oxidase|renal NAD(P)H-oxidase |
| Swissprots | Q7Z7G3 Q5K3R6 B7Z520 Q5K3R5 Q9NPH5 Q86V92 Q5K3R8 Q5K3R4 A8K715 E7EMD7 |
| Accessions | EAW59353 EAW59354 EAW59355 Q9NPH5 AB041035 BAA95695 AF254621 AAF68973 AF261943 AAF87572 AJ704725 CAG28807 AJ704726 CAG28808 AJ704727 CAG28809 AJ704728 CAG28810 AJ704729 CAG28811 AK057189 BAG51879 AK291830 BAF84519 AK298323 BAH12756 AK298328 BAH12759 AK298357 BAH12765 AK298376 BAH12771 AK311381 AK311389 AW207163 AY288918 AAP41109 BC040105 AAH40105 BC051371 AAH51371 BP376400 BU730205 DA970477 JF432404 ADZ15621 XM_006718849 XP_006718912 XM_011542857 XP_011541159 XM_011542858 XP_011541160 XM_011542859 XP_011541161 NM_001143836 NP_001137308 NM_001143837 NP_001137309 NM_001291926 NP_001278855 NM_001291927 NP_001278856 NM_001291929 NP_001278858 NM_001300995 NP_001287924 NM_016931 NP_058627 NR_120406 |
| Function | Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, focal adhesion {ECO:0000305}. Note=May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus. |
| Tissue Specificity | Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells. {ECO:0000269|PubMed:11032835, ECO:0000269|PubMed:11376945, ECO:0000269|PubMed:15210697, ECO:0000269|PubMed:16324151}. |
Human NADPH oxidase 4 peptide - ab104391 from Abcam
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Human NADPH oxidase 4 protein fragment - ab112414 from Abcam
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NADPH oxidase 4 peptide - ab155071 from Abcam
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NADPH oxidase 4 peptide - ab179799 from Abcam
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NADPH oxidase 4 peptide - ab128072 from Abcam
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NOX4 Antibody Blocking Peptide - LS-E2898 from LifeSpan Bioscience
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Nox4 Blocking Peptide - NB110-58849PEP from Novus Biologicals
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Nox4 Partial Recombinant Protein - H00050507-Q01 from Novus Biologicals
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NOX4-Antibody-N-term-Blocking-peptide - BP14025a from Abgent, a WuXi AppTec company
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NOX4 Protein Lysate (APL10349) - APL10349 from Aviva Systems Biology
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NOX4 Protein Lysate (APL10350) - APL10350 from Aviva Systems Biology
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Human NOX4 Protein - abx068291 from Abbexa
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NOX4 Blocking Peptide - abx063847 from Abbexa
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NOX4 - H00050507-Q01 from Acris Antibodies
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NOX4 - H00050507-Q01-10 from Acris Antibodies
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NOX4 - H00050507-Q01-25 from Acris Antibodies
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Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4), Human - 20-8150 from ARP American Research Products
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NOX4 Peptide - 7927P from ProSci
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NOX4 fusion protein - Ag5687 from Proteintech Group
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NOX4 fusion protein - ag6176 from Proteintech Group
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Recombinant Human NOX4 - NOX4-29711TH from Creative Biomart
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Recombinant Human NOX4, GST-tagged - NOX4-1336H from Creative Biomart
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Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) - RPB924Hu01 from Uscn Life Science Inc.
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Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) - RPB924Hu02 from Uscn Life Science Inc.
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Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) - RPB924Mu01 from Uscn Life Science Inc.
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