| Gene Symbol |
NDRG2
|
| Entrez Gene |
57447
|
| Alt Symbol |
SYLD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NDRG family member 2
|
| Other Description |
N-myc downstream regulator 2|N-myc downstream-regulated gene 2 protein|NDR1-related protein NDR2|cytoplasmic protein Ndr1|protein NDRG2|syld709613 protein
|
| Swissprots |
D3DS10 Q567T1 Q96FD3 Q9ULH2 Q96JU0 D3DS07 Q9BQH5 B3KUE3 B7WPD5 Q96PN0 Q96FT0 Q86U46 B7WP11 B4DE86 Q9UN36 Q86U08 Q68DW2
|
| Accessions |
AAK50340 EAW66422 EAW66423 EAW66424 EAW66425 EAW66426 EAW66427 EAW66428 EAW66429 EAW66430 Q9UN36 AB033074 BAA86562 AF087872 AAM10500 AF159092 AAD43131 AF304051 AAL08624 AK024521 AK057843 AK057847 AK090657 AK096999 BAG53405 AK098388 AK130029 AK293514 BAG56997 AL136574 CAB66509 AM392671 CAL37549 AW163815 BC010458 AAH10458 BC011240 AAH11240 BC013209 BC093038 AAH93038 BF341160 BG818977 BI759006 BM810623 BX247987 CAD62321 BX248031 CAD62350 BX647091 BX647748 CB153966 CR749252 CAH18108 DA065447 XM_005267911 XP_005267968 XM_011536994 XP_011535296 XM_011536995 XP_011535297 XM_011536996 XP_011535298 XM_011536997 XP_011535299 XM_011536998 XP_011535300 XM_011536999 XP_011535301 XM_011537000 XP_011535302 XM_011537001 XP_011535303 XM_011537002 XP_011535304 XM_011537003 XP_011535305 XR_943496 NM_001282211 NP_001269140 NM_001282212 NP_001269141 NM_001282213 NP_001269142 NM_001282214 NP_001269143 NM_001282215 NP_001269144 NM_001282216 NP_001269145 NM_016250 NP_057334 NM_201535 NP_963293 NM_201536 NP_963294 NM_201537 NP_963831 NM_201538 NP_963832 NM_201539 NP_963833 NM_201540 NP_963834 NM_201541 NP_963835
|
| Function |
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone {ECO:0000250}. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). {ECO:0000269|PubMed:11352569, ECO:0000269|PubMed:11936845, ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:14572661, ECO:0000269|PubMed:15207261, ECO:0000269|PubMed:15526377, ECO:0000269|PubMed:16103061}.
|