RGS14

Gene Symbol	RGS14
Entrez Gene	10636
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	regulator of G-protein signaling 14
Other Description	regulator of G-protein signalling 14
Swissprots	Q506M1 O43565 Q6ZWA4 Q8TD62 O43566
Accessions	EAW85011 EAW85012 EAW85013 O43566 AF037194 AAB92613 AF037195 AAB92614 AF493936 AAM12650 AI623584 AK098150 BAG53582 AK123382 BAC85600 AY987041 AAY26402 BC014094 AAH14094 BI752372 JF432704 ADZ15921 XM_005265794 XP_005265851 XM_005265795 XP_005265852 NM_006480 NP_006471
Function	Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NG
Subcellular Location	Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15917656}. Membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15917656}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule- organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Relocalizes to the
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RGS14 full length protein - ab130048 from Abcam Category Protein Source E. coli Species Human

RGS14 Antibody Blocking Peptide - LS-E4389 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RGS14 Antibody Blocking Peptide - LS-E25722 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RGS14 Antibody Blocking Peptide - LS-E12035 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RGS14 Recombinant Protein - H00010636-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RGS14 Partial Recombinant Protein - H00010636-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RGS14 Protein - NBP1-98906 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E. coli Species Human

RGS14-Antibody-Center-Blocking-Peptide - BP16695c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RGS14 blocking peptide - GTX15720-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human RGS14 protein - orb169184 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

RGS14 protein (His tag) - 80R-2368 from Fitzgerald Category Protein Prices $295.00 Sizes 20 µg Source E.coli

RGS14 Peptide - AC21-0551-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RGS14 (1-566, His-tag) - AR50449PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

RGS14 (1-566, His-tag) - AR50449PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

RGS14 - H00010636-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RGS14 - H00010636-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RGS14 - H00010636-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RGS14 - H00010636-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RGS14, 1-566aa, Human, His tag, E.coli - 01-P1625 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

RGS14 Peptide - 46-288P from ProSci Category Peptide Species Human

RGS14 fusion protein - Ag9292 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RGS14 fusion protein - Ag9477 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RGS14, 1-566aa, Recombinant Protein - GWB-P0413J from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 20 μg, 100 μg Source E.coli Species Human

Recombinant Human Regulator Of G-Protein Signaling 14, His-tagged - RGS14-6943H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human RGS14, GST-tagged - RGS14-2276H from Creative Biomart Category Protein Source E.coli Species Human

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