Gene Symbol | PROS1 |
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Entrez Gene | 5627 |
Alt Symbol | PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6 |
Species | Human |
Gene Type | protein-coding |
Description | protein S (alpha) |
Other Description | protein Sa|vitamin K-dependent plasma protein S|vitamin K-dependent protein S |
Swissprots | Q7Z715 P07225 A8KAC9 Q9UCZ8 Q15518 D3DN28 |
Accessions | AAA60357 AAD14374 AAD14375 AAO37893 AAP45054 AAT37717 ABD38713 ABD96173 ABD96174 ABD96175 ABI93127 ABI93128 BAC21163 BAC21164 BAC54134 BAC54135 BAC54136 BAC54137 BAC54138 BAC54139 BAC54140 BAC54141 BAC54142 BAC54143 BAC54144 BAC54253 BAC54254 BAC54255 BAC54256 BAC54257 BAC55115 BAD36740 EAW79903 EAW79904 EAW79905 P07225 AI139337 AK292994 BAF85683 AK303895 BAG64828 BC015801 AAH15801 BE677834 BU688598 DB275740 DQ892389 ABM83315 DQ895602 ABM86528 M14338 AAA60181 M15036 AAA36479 X12892 CAA31383 Y00692 CAA68687 XM_005247626 XP_005247683 NM_000313 NP_000304 |
Function | Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. |
Subcellular Location | Secreted. |
Tissue Specificity | Plasma. |
Top Pathways | Complement and coagulation cascades |
Protein S CRISPR/Cas9 KO Plasmid (h) - sc-401491 from Santa Cruz Biotechnology
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Protein S HDR Plasmid (h) - sc-401491-HDR from Santa Cruz Biotechnology
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Protein S Double Nickase Plasmid (h) - sc-401491-NIC from Santa Cruz Biotechnology
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Protein S Double Nickase Plasmid (h2) - sc-401491-NIC-2 from Santa Cruz Biotechnology
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Protein S CRISPR Activation Plasmid (h) - sc-401491-ACT from Santa Cruz Biotechnology
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Protein S CRISPR Activation Plasmid (h2) - sc-401491-ACT-2 from Santa Cruz Biotechnology
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Protein S Lentiviral Activation Particles (h) - sc-401491-LAC from Santa Cruz Biotechnology
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Protein S Lentiviral Activation Particles (h2) - sc-401491-LAC-2 from Santa Cruz Biotechnology
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Protein S siRNA (h) - sc-63328 from Santa Cruz Biotechnology
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Protein S shRNA Plasmid (h) - sc-63328-SH from Santa Cruz Biotechnology
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Protein S shRNA (h) Lentiviral Particles - sc-63328-V from Santa Cruz Biotechnology
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Protein S/PROS1 RNAi - H00005627-R01 from Novus Biologicals
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MISSION® esiRNA - EHU054211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17464 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17464 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08520 from Sigma-Aldrich
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PROS1 siRNA (Human) - CRH3793 from Cohesion Biosciences
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Protein S CRISPR/Cas9 KO Plasmid (h2) - sc-401491-KO-2 from Santa Cruz Biotechnology
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Protein S HDR Plasmid (h2) - sc-401491-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PROS1 (NM_000313.3) - SHH383604 from Creative biogene
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PROS1 shRNA Plasmid (Human) - CHH3793 from Cohesion Biosciences
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PROS1 miRNA 3'UTR clone - MiUTR3H-01884 from Creative biogene
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