CYP21A2

Gene Symbol	CYP21A2
Entrez Gene	1589
Alt Symbol	CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 21, subfamily A, polypeptide 2
Other Description	21-OHase\|cytochrome P450 XXI\|cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2\|cytochrome P450-C21B\|steroid 21-hydroxylase\|steroid 21-monooxygenase
Swissprots	P04033 Q08AG8 Q16749 Q96NU8 A2BHY6 Q16806 P08686 Q5ST44 Q01204
Accessions	AAA52063 AAA52064 AAA52065 AAA59695 AAA59706 AAA83248 AAB59440 AAB67982 AAD13914 AAD45405 ABP99061 ABR68802 ABW38313 ABX82057 ABX82058 ACB54689 ACC64611 ACC64612 ACJ09368 ACL27177 ACS94060 ACS94061 ACS94062 ACS94063 ACS94064 ACS94065 ACS94066 ACT35401 ACT35402 ACT35403 ACT35404 ACT35405 ACT35406 ACT35407 ACT35408 ACT35409 ACT35411 ACT35412 ACT35413 ACT35414 ACT35415 ACT35416 ACT35417 ACT35418 ACT35419 ACT35420 ACT35421 ACT35422 ACT35423 ACT35424 ACT35425 ACT35426 ACT35427 ACT35428 ACT35429 ACT35430 ACT35431 ACT35433 ACT35434 ACT35435 ACT35436 ACT35437 ACT35438 ACT35439 ACT35440 ACT35441 ACT35442 ACT35443 ACT35444 ACT35446 ACT35447 ACT35448 ACT35449 ACT35450 ACT35451 ACT35452 ACT35453 ACT35454 ACT35455 ACT35456 ACT35457 ACT35459 ACT35460 ACT35461 ACT35462 ACT35463 ACT35464 ACT35465 ACT35466 ACT35468 ACT35469 ADM80417 ADM80418 ADM80419 ADM80420 ADM80421 AFK10105 AFK10106 AFK10107 AFK10108 AFK10109 AFK10110 AFK10111 AFK10112 AFK10113 AFK10114 AFK10115 AFK10116 AFK10117 AFK10120 AFK10121 AFK10122 AFK10123 AFK10124 AFK10125 AFK10127 AFK10128 AFK10129 AFK10130 AFK10131 AFK10132 AFK10133 AFK10134 AFK10136 AFK10137 AFK10138 AFK10139 AFK10140 AGZ95071 AHA61373 AHC04400 AHH24255 AIG95649 AIG95650 CAA41702 CAA41703 CAA41704 CAA41706 CAA41707 CAA41709 CAA41710 CAB89301 CAD24050 EAX03570 EAX03571 P08686 AK054616 BAB70774 AK314651 BAG37212 AM086564 CAJ31103 AM086565 CAJ31104 AM183945 CAJ75799 AM183946 CAJ75800 AM183947 CAJ75801 AM183948 CAJ75802 AM183949 CAJ75803 AM183950 CAJ75804 AM183951 CAJ75805 AV708092 BC125181 AAI25182 BC125182 AAI25183 BC128535 AAI28536 BP198315 CD013985 CD013987 DA008890 DA014348 DB295152 M17252 AAA59985 XM_011514314 XP_011512616 XM_011547193 XP_011545495 XM_011547605 XP_011545907 XM_011548387 XP_011546689 NM_000500 NP_000491 NM_001128590 NP_001122062
Function	Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Top Pathways	Steroid hormone biosynthesis

CYP21A2 (C-17) - sc-48466 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CYP21A2 (C-17): sc-48466. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing membrane and cytoplasmic staining of glandular cells.

CYP21A2 (H-300) - sc-134566 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 antibody - ab189420 from Abcam

Prices	$407.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CYP21A2 antibody (ab189420) at 1/500 dilutionLane 1 : 293 cell extractsLane 2 : 293 cell extracts with synthesized peptide

Anti-CYP21A2 antibody - ab64887 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CYP21A2 antibody (ab64887) at 1/500 dilutionLane 1 : extracts from 293 cells (5-30µg total protein)Lane 2 : extracts from 293 cells (5-30µg total protein) and 5-10µg of the immunising peptide.

Anti-CYP21A2 antibody - ab129862 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 antibody (ab129862) at 1/100 dilution + CEM cell line lysates at 35 µgdeveloped using the ECL technique

Anti-CYP21A2 antibody - ab151982 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 antibody (ab151982) at 1/1000 dilution + Molt4 whole cell lysate at 30 µg

Anti-CYP21A2 antibody - N-terminal - ab80208 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 antibody - N-terminal (ab80208) at 1/50 dilution + NCI-H460 cell line lysates at 35 µg

Anti-CYP21A2 Antibody (aa159-188) - LS-C320717 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa151-200) IHC-plus™ - LS-B9248 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CYP21A2 Antibody (aa106-389) - LS-C293632 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa37-264) - LS-C293633 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa200-414) - LS-C293635 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa314-363) IHC-plus™ - LS-B9758 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9758 concentration 5 ug/ml.

Anti-CYP21A2 Antibody (aa224-253) IHC-plus™ - LS-B12176 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CYP21A2 Antibody (aa23-39) - LS-C3015 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (N-Terminus) - LS-C97494 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot of CYP21A2 Antibody in 293, HL-60 cell line lysates (35 ug/lane). CYP21A2 (arrow) was detected using the purified antibody.

Anti-CYP21A2 Antibody (Phe177) - LS-C191998 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody - LS-C109472 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Sample (30 ug of whole cell lysate). A: Molt-4. 7.5% SDS PAGE. CYP21A2 antibody diluted at 1:1000.

Anti-CYP21A2 Antibody (aa159-188, APC) - LS-C221963 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa159-188, AP) - LS-C221962 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa159-188, Azide-free, HRP) - LS-C221966 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa159-188) - LS-C167211 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

CYP21A2 Antibody western blot of CEM cell line lysates (35 ug/lane). The CYP21A2 antibody detected the CYP21A2 protein (arrow).

Anti-CYP21A2 Antibody (aa159-188, Biotin) - LS-C221964 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa159-188, FITC) - LS-C221965 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CYP21A2 Antibody (aa159-188, PE) - LS-C221967 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

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