NRXN1
| Gene Symbol | NRXN1 |
|---|---|
| Entrez Gene | 9378 |
| Alt Symbol | Hs.22998, PTHSL2, SCZD17 |
| Species | Human |
| Gene Type | protein-coding |
| Description | neurexin 1 |
| Other Description | neurexin I|neurexin-1-beta |
| Swissprots | Q9H3M2 Q53TQ1 Q9ULB1 Q9C081 P58400 Q9UDM6 A7KRL9 O60323 Q9C080 Q53TJ9 Q9C079 |
| Accessions | AAF03536 AAG38120 AAG59602 AAG59642 AAK06387 AAY14894 AAY14944 EAX00182 EAX00183 EAX00184 EAX00185 EAX00186 P58400 Q9ULB1 AB011150 BAA25504 AB035356 BAA87821 AF064842 AF087975 AK093260 AK124726 AK295773 BAG58597 BC046631 AAH46631 BC125179 AAI25180 BC125180 AAI25181 BC150247 AAI50248 BM021375 BX647616 CAI46085 DA153976 DA168874 DA320230 EF539882 ABS86974 XM_005264642 XP_005264699 XM_005264643 XP_005264700 XM_006712137 XP_006712200 XM_006712140 XP_006712203 XM_006712141 XP_006712204 XM_011533167 XP_011531469 XM_011533168 XP_011531470 XM_011533169 XP_011531471 XM_011533170 XP_011531472 XM_011533171 XP_011531473 XM_011533172 XP_011531474 XM_011533173 XP_011531475 XM_011533174 XP_011531476 XM_011533175 XP_011531477 XM_011533176 XP_011531478 XM_011533177 XP_011531479 XM_011533178 XP_011531480 XM_011533179 XP_011531481 XM_011533180 XP_011531482 XM_011533181 XP_011531483 XM_011533182 XP_011531484 XM_011533183 XP_011531485 XM_011533184 XP_011531486 NM_001135659 NP_001129131 NM_004801 NP_004792 NM_138735 NP_620072 |
| Function | Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localized on the pre- synaptic membrane. {ECO:0000250}. |
| Tissue Specificity | Brain. {ECO:0000269|PubMed:9628581}. |
| Top Pathways | Cell adhesion molecules (CAMs) |
neurexin I CRISPR/Cas9 KO Plasmid (h) - sc-401872 from Santa Cruz Biotechnology
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neurexin I HDR Plasmid (h) - sc-401872-HDR from Santa Cruz Biotechnology
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neurexin I Double Nickase Plasmid (h) - sc-401872-NIC from Santa Cruz Biotechnology
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neurexin I Double Nickase Plasmid (h2) - sc-401872-NIC-2 from Santa Cruz Biotechnology
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neurexin I CRISPR Activation Plasmid (h) - sc-401872-ACT from Santa Cruz Biotechnology
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neurexin I CRISPR Activation Plasmid (h2) - sc-401872-ACT-2 from Santa Cruz Biotechnology
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neurexin I Lentiviral Activation Particles (h) - sc-401872-LAC from Santa Cruz Biotechnology
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neurexin I Lentiviral Activation Particles (h2) - sc-401872-LAC-2 from Santa Cruz Biotechnology
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neurexin I siRNA (h) - sc-42050 from Santa Cruz Biotechnology
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neurexin I shRNA Plasmid (h) - sc-42050-SH from Santa Cruz Biotechnology
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neurexin I shRNA (h) Lentiviral Particles - sc-42050-V from Santa Cruz Biotechnology
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NRXN1 RNAi - H00009378-R03 from Novus Biologicals
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NRXN1 RNAi - H00009378-R04 from Novus Biologicals
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MISSION® esiRNA - EHU123051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15525 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15525 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12708 from Sigma-Aldrich
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NRXN1 siRNA (Human) - CRH6214 from Cohesion Biosciences
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NRXN1 siRNA (Human) - CRH6215 from Cohesion Biosciences
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shRNA set against Human NRXN1 (NM_004801.4) - SHH355252 from Creative biogene
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Human NRXN1 siRNA - orb266716 from Biorbyt
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Human NRXN1 siRNA - orb266717 from Biorbyt
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NRXN1 shRNA Plasmid (Human) - CHH6214 from Cohesion Biosciences
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NRXN1 shRNA Plasmid (Human) - CHH6215 from Cohesion Biosciences
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