| Gene Symbol | ALDH3A1 |
|---|---|
| Entrez Gene | 218 |
| Alt Symbol | ALDH3, ALDHIII |
| Species | Human |
| Gene Type | protein-coding |
| Description | aldehyde dehydrogenase 3 family, member A1 |
| Other Description | aldehyde dehydrogenase isozyme 3|aldehyde dehydrogenase type III|aldehyde dehydrogenase, dimeric NADP-preferring|stomach aldehyde dehydrogenase |
| Swissprots | Q9BT37 P30838 A8K828 |
| Accessions | EAW50908 EAW50909 P30838 AK091272 AK093755 BAG52758 AK093877 BAC04239 AK225505 AK225513 AK292193 BAF84882 AK314584 BAG37160 BC004102 AAH04102 BC004370 AAH04370 BC008892 AAH08892 BC021194 AAH21194 BM979497 BT007102 AAP35766 CV575863 DA427150 DA445491 DQ892988 ABM83914 M74542 AAA51696 M77477 AAB46377 S61044 AAB26658 XM_005256522 XP_005256579 XM_005256523 XP_005256580 XM_005256524 XP_005256581 XM_011523730 XP_011522032 XM_011523731 XP_011522033 NM_000691 NP_000682 NM_001135167 NP_001128639 NM_001135168 NP_001128640 |
| Function | ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | High levels in stomach, esophagus and lung; low level in the liver and kidney. |
| Top Pathways | Chemical carcinogenesis, Glycolysis / Gluconeogenesis, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450, Tyrosine metabolism |