CCNH

Gene Symbol	CCNH
Entrez Gene	902
Alt Symbol	CAK, CycH, p34, p37
Species	Human
Gene Type	protein-coding
Description	cyclin H
Other Description	CAK complex subunit|CDK-activating kinase complex subunit|MO15-associated protein|cyclin-H|cyclin-dependent kinase-activating kinase complex subunit
Swissprots	Q8TBL9 P51946 Q53X72
Accessions	AAL74271 EAW95934 EAW95935 P51946 AB209342 BAD92579 AI761780 AK094534 AK291720 BAF84409 BC005280 AAH05280 BC016705 AAH16705 BC016823 AAH16823 BC022351 AAH22351 BF510957 BG718714 BP244381 BX537673 CB240639 CR407658 CAG28586 DA079651 DQ892550 ABM83476 DQ895761 ABM86687 U11791 AAA21361 U12685 AAA57006 XM_005248627 XP_005248684 XM_005248629 XP_005248686 XM_011543706 XP_011542008 NM_001199189 NP_001186118 NM_001239 NP_001230
Function	Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:7533895}.
Subcellular Location	Nucleus.
Top Pathways	Cell cycle, Nucleotide excision repair, Basal transcription factors

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cyclin H full length protein - ab39435 from Abcam Category Protein Source E. coli Species Human

Human Cyclin H full length protein - ab174062 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Cyclin H full length protein - ab95351 from Abcam Category Protein Source E. coli Species Human

CCNH / Cyclin H Antibody Blocking Peptide - LS-E609 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCNH / Cyclin H Antibody Blocking Peptide - LS-E837 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCNH / Cyclin H Antibody Blocking Peptide - LS-E10507 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCNH / Cyclin H Antibody Blocking Peptide - LS-E10950 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CCNH / Cyclin H Antibody Blocking Peptide - LS-E10951 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cyclin H Recombinant Protein - H00000902-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Cyclin H Partial Recombinant Protein - H00000902-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Cyclin H Protein - NBP1-44483 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

CCNH-Antibody-C-term-Blocking-peptide - BP10940b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CCNH-Antibody-N-term-Blocking-peptide - BP11210a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CCNH protein - orb80777 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Cyclin H (1-323, His-tag) - AR09425PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

Cyclin H (1-323, His-tag) - AR09425PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

Cyclin H - H00000902-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cyclin H - H00000902-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cyclin H - H00000902-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cyclin H - H00000902-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cyclin H, 1- 323 aa, Human, His-tagged, Recombinant, E.coli - 01-1810-H from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

CCNH fusion protein - Ag1088 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CCNH Human - PKPS-371 from NeoScientific Category Protein Prices $65.00, $169.00, $2,925.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Cyclin-H Protein - BP002499-PKA-364 from Syd Labs Category Protein Prices $160.00, $2,250.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Human

Cyclin H, 1- 323 aa, Recombinant Protein - GWB-P1513E from Genway Biotech Category Protein Prices $260.00, $780.00 Sizes 100 μg, 500 μg Source E.coli Species Human

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