| Gene Symbol | St6galnac4 |
|---|---|
| Entrez Gene | 20448 |
| Alt Symbol | SIAT7-D, ST6GalNAcIV, Siat7d |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 |
| Other Description | GalNAc alpha-2,6-sialyltransferase|ST6 neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4|ST6GalNAc IV|Sia-alpha-2-3-Gal-beta-1-3-GalNAc GalNAc-alpha-2,6-sialyltransferase|alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase|neuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase|sialyltransferase 7 ((alpha-N-acetylneuraminyl 2,3-betagalactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) D|sialyltransferase 7D |
| Swissprots | Q9QUP9 Q9R2B6 Q9R2B5 O88725 Q9JHP0 |
| Accessions | CAB93944 CAB93945 CAB93946 CAB93947 CAB93948 EDL08556 Q9R2B6 AJ007310 CAA07446 AK007601 AK085730 BAC39523 AK144884 BAE26116 AK153036 BAE31668 AK155956 AK159712 BAE35308 AK161559 BAE36463 AK179544 AK182829 AK205547 BC044734 BC056451 AAH56451 BC086784 AAH86784 BY276898 Y15779 CAB43507 Y15780 CAB43514 NM_001276425 NP_001263354 NM_011373 NP_035503 |
| Function | Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. Prefers glycoproteins to glycolipids. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | High expression in brain and colon and to a lesser extent in lung, heart, kidney, spleen and thymus. {ECO:0000269|PubMed:10207017}. |
| Top Pathways | Glycosphingolipid biosynthesis - ganglio series |
Sialyltransferase 7D CRISPR/Cas9 KO Plasmid (m) - sc-422941 from Santa Cruz Biotechnology
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Sialyltransferase 7D HDR Plasmid (m) - sc-422941-HDR from Santa Cruz Biotechnology
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Sialyltransferase 7D Double Nickase Plasmid (m) - sc-422941-NIC from Santa Cruz Biotechnology
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Sialyltransferase 7D Double Nickase Plasmid (m2) - sc-422941-NIC-2 from Santa Cruz Biotechnology
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Sialyltransferase 7D CRISPR Activation Plasmid (m) - sc-422941-ACT from Santa Cruz Biotechnology
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Sialyltransferase 7D CRISPR Activation Plasmid (m2) - sc-422941-ACT-2 from Santa Cruz Biotechnology
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Sialyltransferase 7D Lentiviral Activation Particles (m) - sc-422941-LAC from Santa Cruz Biotechnology
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Sialyltransferase 7D Lentiviral Activation Particles (m2) - sc-422941-LAC-2 from Santa Cruz Biotechnology
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Sialyltransferase 7D siRNA (m) - sc-63021 from Santa Cruz Biotechnology
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Sialyltransferase 7D shRNA Plasmid (m) - sc-63021-SH from Santa Cruz Biotechnology
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Sialyltransferase 7D shRNA (m) Lentiviral Particles - sc-63021-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU193751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42128 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42128 from Sigma-Aldrich
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ST6GALNAC4 siRNA (Mouse) - CRM3723 from Cohesion Biosciences
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ST6GALNAC4 - MBS8231358 from MyBioSource
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shRNA set against Mouse ST6GALNAC4 (NM_011373.2) - SHH418948 from Creative biogene
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shRNA set against Mouse St6galnac4(NM_011373.2) - SHL038574 from Creative biogene
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Mouse ST6GALNAC4 siRNA - orb283199 from Biorbyt
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ST6GALNAC4 shRNA Plasmid (Mouse) - CHM3723 from Cohesion Biosciences
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ST6GALNAC4 miRNA 3'UTR clone - MiUTR1M-11282 from Creative biogene
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