| Gene Symbol |
Akt1
|
| Entrez Gene |
41957
|
| Alt Symbol |
AKT, AKT/PKB, AKT1, Akt, Akt/PKB, Akt1, PKB, CG4006, D-Akt, DAKT1, DAKT1/PKB, DAkt, DAkt1, DPKB, DRAC-PK, DRAC-PK66, DRAC-PK85, Dakt, Dakt1, Dmel\CG4006, Dpkb, PKB, PKB/AKT, PKB/Akt, PKB/dAKT, RAC, RacPK, akt, akt1, dAKT, dAKT/dPKB, dAKT1, dAkt, dAkt/PKB,
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
CG4006 gene product from transcript CG4006-RE
|
| Other Description |
Akt kinase|Akt1-PA|Akt1-PB|Akt1-PC|Akt1-PD|Akt1-PE|CG4006-PA|CG4006-PB|CG4006-PC|CG4006-PD|CG4006-PE|dAkt kinase|protein kinase B|related to PKA to PKC protein kinases|related to the A and C kinases
|
| Swissprots |
Q24470 Q8T9A5 Q24469 Q24293 Q8INB9 Q7JN11 Q9VEY7 Q0KI65
|
| Accessions |
AAF55275 AAF55276 AAN13699 AHN57352 AHN57353 CAA58500 Q8INB9 AY069856 AAL40001 NM_001300424 NP_001287353 NM_001300425 NP_001287354 NM_169705 NP_732113 NM_169706 NP_732114 NM_169707 NP_732115
|
| Function |
Serine/threonine kinase involved in various developmental processes. During early embryogenesis, acts as a survival protein. During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination. Also regulates tracheal cell migration. Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor. Controls follicle cell size during oogenesis. May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex. Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth. {ECO:0000269|PubMed:10587646, ECO:0000269|PubMed:10962553, ECO:0000269|PubMed:11740943, ECO:0000269|PubMed:11752451, ECO:0000269|PubMed:11872800, ECO:0000269|PubMed:12172554, ECO:0000269|PubMed:12893776, ECO:0000269|PubMed:14525946, ECO:0000269|PubMed:15466161,
|
| Subcellular Location |
Cytoplasm, cytosol. Cell membrane. Note=Recruited to plasma membrane upon activation.
|
| Tissue Specificity |
Ubiquitously expressed. Present in ovary, where it is concentrated at the basal side of follicle cells. {ECO:0000269|PubMed:7876156}.
|
| Top Pathways |
Jak-STAT signaling pathway, mTOR signaling pathway
|