| Gene Symbol |
ARF1
|
| Entrez Gene |
338058
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
ADP-ribosylation factor 1
|
| Other Description |
-
|
| Swissprots |
A5D7F1 Q3SZG1 P84080
|
| Accessions |
DAA28323 P84080 BC102874 AAI02875 BC140532 AAI40533 J03275 AAA30361 XM_005208399 XP_005208456 XM_005208400 XP_005208457 NM_176653 NP_788826
|
| Function |
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).
|
| Subcellular Location |
Golgi apparatus. Cytoplasm, perinuclear region {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
|
| Top Pathways |
Endocytosis, Legionellosis
|