| Gene Symbol |
TUBB6
|
| Entrez Gene |
84617
|
| Alt Symbol |
HsT1601, TUBB-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tubulin, beta 6 class V
|
| Other Description |
class V beta-tubulin|tubulin beta MGC4083|tubulin beta class V|tubulin beta-6 chain
|
| Swissprots |
B3KM76 Q9HA42 Q9BUF5
|
| Accessions |
EAX01553 EAX01554 Q9BUF5 AK001295 BAG50888 AK022340 BAB14016 AK092677 BAG52593 AK098440 AK298196 BAG60466 AK304616 BAG65398 AK311364 BC002654 AAH02654 BC111374 AAI11375 BP268791 CD364877 CN367565 CX866060 DA693982 DA765796 DB271698 DQ893486 ABM84412 DQ896394 ABM87393 NM_001303524 NP_001290453 NM_001303525 NP_001290454 NM_001303526 NP_001290455 NM_001303527 NP_001290456 NM_001303528 NP_001290457 NM_001303529 NP_001290458 NM_001303530 NP_001290459 NM_032525 NP_115914
|
| Function |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Maximal expression in breast and lung, where it represents around 10% of all beta-tubulins. Largely decreased expression in most cancerous tissues. {ECO:0000269|PubMed:20191564}.
|
| Top Pathways |
Gap junction, Pathogenic Escherichia coli infection, Phagosome
|
![Western Blot: TUBB6 Overexpression Lysate (Adult Normal) [NBL1-17442] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TUBB6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1552_TUBB6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17442-img0002.jpg)