| Gene Symbol |
GMPPA
|
| Entrez Gene |
29926
|
| Alt Symbol |
AAMR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GDP-mannose pyrophosphorylase A
|
| Other Description |
GMPP-alpha|GTP-mannose-1-phosphate guanylyltransferase alpha|mannose-1-phosphate guanyltransferase alpha|mannose-1-phosphate guanylyltransferase (GDP)
|
| Swissprots |
Q9Y5P5 B3KMT4 A6NJ74 Q9NWC3 Q53GI0 A8K3Q6 Q96IJ6
|
| Accessions |
AAY15053 CAE90490 EAW70755 EAW70756 EAW70757 EAW70758 EAW70759 Q96IJ6 AB209592 BAD92829 AF135422 AAD38517 AK000999 BAA91460 AK022578 BAG51096 AK222951 BAD96671 AK290671 BAF83360 AK296193 BAG58922 BC007456 AAH07456 BC014266 BP284488 BP366441 CN309976 DQ892873 ABM83799 DQ896121 ABM87120 XM_005246483 XP_005246540 XM_005246485 XP_005246542 XM_005246486 XP_005246543 XM_011511032 XP_011509334 XM_011511033 XP_011509335 XM_011511034 XP_011509336 XM_011511035 XP_011509337 XR_241307 NM_013335 NP_037467 NM_205847 NP_995319
|
| Function |
May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose. {ECO:0000269|PubMed:24035193}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:24035193}. Note=Myc-tagged GMPPA shows a diffuse cytoplasmic and nuclear pattern in transfected COS-7 cells.
|
| Tissue Specificity |
Expressed in fibroblasts (at protein level). {ECO:0000269|PubMed:24035193}.
|
| Top Pathways |
Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism
|