| Gene Symbol |
DMTF1
|
| Entrez Gene |
9988
|
| Alt Symbol |
DMP1, DMTF, MRUL, hDMP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin D binding myb-like transcription factor 1
|
| Other Description |
cyclin D-binding Myb-like protein|cyclin-D-binding Myb-like transcription factor 1|cyclin-D-interacting Myb-like protein 1|hDMTF1
|
| Swissprots |
Q59G79 Q9H2Z3 Q969T2 Q05C48 Q9Y222 B2RBE1 B4DJS5 Q6IS13 Q9H2Z2
|
| Accessions |
AAD43181 EAW76962 EAW76963 EAW76964 EAW76965 Q9Y222 AA258783 AB209230 BAD92467 AF052102 AF084530 AAC33480 AF202144 AAG35613 AF202145 AAG35614 AK002073 BAG51010 AK057917 AK095828 AK123259 BAG53884 AK126664 BAG54353 AK295144 BAG58163 AK296211 BAG58937 AK314622 BAG37188 BC007418 AAH07418 BC007447 AAH07447 BC029370 AAH29370 BC070064 AAH70064 DB061156 DB069894 DC339431 EL736930 XM_005250734 XP_005250791 XM_006716202 XP_006716265 XM_011516731 XP_011515033 XM_011516732 XP_011515034 XM_011516733 XP_011515035 XM_011516734 XP_011515036 XM_011516735 XP_011515037 XM_011516736 XP_011515038 XM_011516737 XP_011515039 XM_011516738 XP_011515040 XM_011516739 XP_011515041 XM_011516740 XP_011515042 XM_011516741 XP_011515043 XM_011516742 XP_011515044 NM_001142326 NP_001135798 NM_001142327 NP_001135799 NM_021145 NP_066968 NR_024549 NR_024550
|
| Function |
Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1. {ECO:0000250, ECO:0000269|PubMed:12917399}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00625, ECO:0000269|PubMed:17936562}.
|
| Tissue Specificity |
Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non- small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7. {ECO
|