| Gene Symbol | POLR3C |
|---|---|
| Entrez Gene | 10623 |
| Alt Symbol | RPC3, RPC62 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (RNA) III (DNA directed) polypeptide C (62kD) |
| Other Description | DNA-directed III 62 kDa polypeptide|DNA-directed RNA polymerase III subunit C|DNA-directed RNA polymerase III subunit RPC3|RNA polymerase III 62 kDa subunit|RNA polymerase III subunit C3 |
| Swissprots | Q9Y3R6 O15317 Q9BUI4 |
| Accessions | CAB41919 EAW71434 EAW71435 EAW71436 Q9BUI4 AK223413 BAD97133 AY091463 AAM12033 BC002586 AAH02586 BC004424 AAH04424 BC053590 BE258456 BI831011 BQ932484 DA291657 DA816269 JF432112 ADZ15329 U93867 AAB63675 XM_005272927 XP_005272984 XM_005272928 XP_005272985 XM_011509078 XP_011507380 XR_921720 XR_921721 XR_921722 XR_921723 NM_001303456 NP_001290385 NM_006468 NP_006459 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000269|PubMed:19609254, E |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Top Pathways | Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |