DNAH2
| Gene Symbol | DNAH2 |
|---|---|
| Entrez Gene | 146754 |
| Alt Symbol | DNAHC2, DNHD3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynein, axonemal, heavy chain 2 |
| Other Description | axonemal beta dynein heavy chain 2|ciliary dynein heavy chain 2|dynein heavy chain 2, axonemal|dynein heavy chain domain-containing protein 3|dynein, axonemal, heavy polypeptide 2 |
| Swissprots | O15434 B5MDX5 Q6ZR42 Q9P225 Q6PIH3 A8K992 |
| Accessions | AAB82760 CCQ43655 EAW90129 EAW90130 EAW90131 Q9P225 AB040936 BAA96027 AK128517 AK292607 BAF85296 BC034225 AAH34225 BQ638815 BX648163 XM_011523663 XP_011521965 XM_011523664 XP_011521966 XM_011523665 XP_011521967 XM_011523666 XP_011521968 XM_011523667 XP_011521969 XM_011523668 XP_011521970 XM_011523669 XP_011521971 XM_011523670 XP_011521972 NM_001303270 NP_001290199 NM_020877 NP_065928 |
| Function | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}. |
| Tissue Specificity | Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung. {ECO:0000269|PubMed:9256245}. |
| Top Pathways | Huntington's disease |
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