EYA1

Gene Symbol	EYA1
Entrez Gene	2138
Alt Symbol	BOP, BOR, BOS1, OFC1
Species	Human
Gene Type	protein-coding
Description	EYA transcriptional coactivator and phosphatase 1
Other Description	eyes absent homolog 1
Swissprots	A6NHQ0 G5E9R4 Q0P516 Q8WX80 Q99502
Accessions	CAA71309 CAH05072 CAH05073 EAW86973 EAW86974 EAW86975 EAW86976 EAW86977 EAW86978 EAW86979 EAW86980 Q99502 AF467247 AAL73437 AJ000097 CAA03922 AJ000098 CAA03923 AK127798 BAG54573 AK295897 BAG58690 AK307379 BC035138 BC048982 BC121798 AAI21799 BC121799 AAI21800 BI497179 BQ223588 BU679404 DA618315 DA746489 DB004805 DC360066 DC409057 LN608216 LN608217 LN608218 XM_011517481 XP_011515783 XM_011517482 XP_011515784 XM_011517483 XP_011515785 XM_011517484 XP_011515786 XM_011517485 XP_011515787 XM_011517486 XP_011515788 XM_011517487 XP_011515789 XM_011517488 XP_011515790 XM_011517489 XP_011515791 XM_011517490 XP_011515792 XM_011517491 XP_011515793 XM_011517492 XP_011515794 NM_000503 NP_000494 NM_001288574 NP_001275503 NM_001288575 NP_001275504 NM_172058 NP_742055 NM_172059 NP_742056 NM_172060 NP_742057
Function	Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2. {ECO:0000269|PubMed:19234442}.
Subcellular Location	Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity	In the embryo, highly expressed in kidney with lower levels in brain. Weakly expressed in lung. In the adult, highly expressed in heart and skeletal muscle. Weakly expressed in brain and liver. No expression in eye or kidney.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EYA1 protein fragment - ab114638 from Abcam Category Protein Source Wheat germ Species Human

EYA1 Antibody Blocking Peptide - LS-E1681 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EYA1 Antibody Blocking Peptide - LS-E14530 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EYA1 Antibody Blocking Peptide - LS-E27224 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EYA1 Blocking Peptide - LS-E11360 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EYA1 Antibody Blocking Peptide - LS-E11361 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EYA1 Protein - H00002138-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EYA1-Antibody-N-term-Blocking-peptide - BP12446a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GOSR2 protein (His tag) - 80R-2715 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

EYA1 Blocking Peptide - abx161092 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

EYA1 Peptide - AC21-2045-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

EYA1 - H00002138-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EYA1 - H00002138-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EYA1 Peptide - 42-258P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

EYA1 fusion protein - ag18489 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

GOSR2 Human - PRPS-1406 from NeoScientific Category Protein Prices $65.00, $169.00, $1,560.00 Sizes 2 µg, 10 µg, 100 µg Source E.coli. Species Human

Recombinant Human EYA1 - EYA1-26641TH from Creative Biomart Category Protein Source Wheat germ

EYA1 Blocking Peptide - CBP3591 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Zebrafish

Recombinant Human Eyes absent homolog 1(EYA1) - CSB-YP857862HU CSB-EP857862HU CSB-BP857862HU CSB-MP857862HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EYA1, Peptide - MBS426768 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

Recombinant Human EYA1 protein - EYA1-48H from Creative Biomart Category Protein Source E.coli Species Human

EYA1 Peptide, Human - M34GP05156H from Creative Peptides Category Peptide Source Synthetic. Species Human

GOSR2 - PAT-82010-1 from Nordic BioSite Category Protein Species Human

GOSR2 - PAT-82010-2 from Nordic BioSite Category Protein Species Human

EYA1 Recombinant Protein Antigen - NBP2-58069PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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