| Gene Symbol |
CKAP2
|
| Entrez Gene |
26586
|
| Alt Symbol |
LB1, TMAP, se20-10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytoskeleton associated protein 2
|
| Other Description |
CTCL tumor antigen se20-10|cytoskeleton-associated protein 2|tumor- and microtubule-associated protein|tumor-associated microtubule-associated protein
|
| Swissprots |
Q9NVG4 Q3KRA5 A5YM58 Q8WWK9 Q9H988 Q5VXB4 Q8IWV5 E9PD90 Q96FH9 Q8IWV6 Q9HC49 Q9H012 Q9H0D0 A2BDE0 B4DR35
|
| Accessions |
CAD22295 EAW55889 EAW55890 Q8WWK9 AA308726 AF177227 AAG33675 AI499799 AK001611 BAA91788 AK022982 BAB14345 AK027103 AK299083 BAG61147 AL136848 CAB66782 AY062261 AAL47212 AY062262 AAL47213 BC010901 AAH10901 BC066920 BC105806 AAI05807 BC130296 AAI30297 BC136332 AAI36333 BM541375 DB512858 EC439890 EF560732 ABQ59042 EU832808 ACE87819 GQ129239 ACT64373 HQ258356 ADR83110 Y15758 CAC17466 XM_005266344 XP_005266401 XM_011535043 XP_011533345 NM_001098525 NP_001091995 NM_001286686 NP_001273615 NM_001286687 NP_001273616 NM_018204 NP_060674
|
| Function |
Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome- proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
|
| Tissue Specificity |
Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney. {ECO:0000269|PubMed:9771967}.
|