Gene Symbol | PSMC4 |
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Entrez Gene | 5704 |
Alt Symbol | MIP224, RPT3, S6, TBP-7, TBP7 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) 26S subunit, ATPase, 4 |
Other Description | 26S protease regulatory subunit 6B|26S proteasome AAA-ATPase subunit RPT3|MB67-interacting protein|Tat-binding protein 7|protease 26S subunit 6 |
Swissprots | Q96FV5 Q9UEX3 Q9UBM3 P43686 |
Accessions | AAD39267 EAW56928 EAW56929 P43686 AF020736 AAC32612 AF038965 AAC26843 AK290285 BAF82974 AK310135 AK313183 BAG36000 BC000343 AAH00343 BC010396 AAH10396 BC014488 AAH14488 BC018811 BI828251 BT007232 AAP35896 DQ891875 ABM82801 DQ894876 ABM85802 U27515 AAC99817 NM_006503 NP_006494 NM_153001 NP_694546 |
Function | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. {ECO:0000269|PubMed:8060531}. |
Subcellular Location | Cytoplasm. Nucleus. |
Top Pathways | Proteasome, Epstein-Barr virus infection |
PSMC4 CRISPR/Cas9 KO Plasmid (h) - sc-403885 from Santa Cruz Biotechnology
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PSMC4 HDR Plasmid (h) - sc-403885-HDR from Santa Cruz Biotechnology
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PSMC4 Double Nickase Plasmid (h) - sc-403885-NIC from Santa Cruz Biotechnology
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PSMC4 Double Nickase Plasmid (h2) - sc-403885-NIC-2 from Santa Cruz Biotechnology
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PSMC4 CRISPR Activation Plasmid (h) - sc-403885-ACT from Santa Cruz Biotechnology
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PSMC4 CRISPR Activation Plasmid (h2) - sc-403885-ACT-2 from Santa Cruz Biotechnology
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PSMC4 Lentiviral Activation Particles (h) - sc-403885-LAC from Santa Cruz Biotechnology
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PSMC4 Lentiviral Activation Particles (h2) - sc-403885-LAC-2 from Santa Cruz Biotechnology
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PSMC4 siRNA (h) - sc-45851 from Santa Cruz Biotechnology
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PSMC4 shRNA Plasmid (h) - sc-45851-SH from Santa Cruz Biotechnology
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PSMC4 shRNA (h) Lentiviral Particles - sc-45851-V from Santa Cruz Biotechnology
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Tbp7 RNAi - H00005704-R01 from Novus Biologicals
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Tbp7 RNAi - H00005704-R02 from Novus Biologicals
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MISSION® esiRNA - EHU001601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17611 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00202 from Sigma-Aldrich
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PSMC4 siRNA (Human) - CRH3850 from Cohesion Biosciences
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shRNA set against Human PSMC4 (NM_006503.3) - SHH385312 from Creative biogene
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Human PSMC4 siRNA - orb264352 from Biorbyt
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PSMC4 shRNA Plasmid (Human) - CHH3850 from Cohesion Biosciences
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PSMC4 miRNA 3'UTR clone - MiUTR3H-05248 from Creative biogene
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PSMC4 miRNA 3'UTR clone - MiUTR3H-05249 from Creative biogene
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