| Gene Symbol |
Pcnt
|
| Entrez Gene |
18541
|
| Alt Symbol |
AW476095, C86676, KEN, Pcnt2, kendrin, m239Asp, m275Asp
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
pericentrin (kendrin)
|
| Other Description |
pericentrin|pericentrin 2|pericentrin-250|pericentrin-360
|
| Swissprots |
A0JBT0 P48725 A0JBT1
|
| Accessions |
EDL31853 P48725 AB207233 BAF36559 AB207234 BAF36560 AK029906 BAC26669 AK052041 AK122275 BAC65557 AK145315 BAE26361 AK163352 BAE37314 AY179559 AAO24322 BB840023 BC034865 BC039661 BC055467 AAH55467 BC085244 BC100380 AAI00381 BC172748 AAI72748 BG084686 BG088995 BG143796 BG923243 BI734431 BM219062 BU518252 BY711114 XM_006513348 XP_006513411 XM_006513353 XP_006513416 XM_006513356 XP_006513419 XM_011243382 XP_011241684 XM_011243383 XP_011241685 XM_011243384 XP_011241686 XM_011243385 XP_011241687 XM_011243386 XP_011241688 XM_011243387 XP_011241689 NM_001282992 NP_001269921 NM_008787 NP_032813
|
| Function |
Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in heart and lung (at protein level). Expressed in kidney, thymus, liver, brain, muscle, testis, spleen, lung and heart. {ECO:0000269|PubMed:17084386}.
|
