| Gene Symbol | Cyp46a1 |
|---|---|
| Entrez Gene | 13116 |
| Alt Symbol | Cyp46 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 46, subfamily a, polypeptide 1 |
| Other Description | CH24H|cholesterol 24-hydroxylase|cholestrol 24-hydroxylase|cytochrome P450 46A1|cytochrome P450, 46 (cholesterol 24-hydroxylase)|cytochrome P450, 46a1 (cholesterol 24-hydroxylase) |
| Swissprots | Q9WVK8 |
| Accessions | EDL18715 EDL18716 Q9WVK8 AF094479 AAD41243 AK140740 BAE24462 BC018307 AAH18307 XM_006515456 XP_006515519 XR_381477 NM_010010 NP_034140 |
| Function | Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in high level in brain (cerebral cortex, hippocampus, dentate gyrus and thalamus) and in lower levels in testis and liver. Brain's expression increased linearly with age. |
| Top Pathways | Primary bile acid biosynthesis |