| Gene Symbol |
Polr1b
|
| Entrez Gene |
20017
|
| Alt Symbol |
128kDa, D630020H17Rik, RPA116, RPA135, RPA2, Rpo1-2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) I polypeptide B
|
| Other Description |
DNA-directed RNA polymerase I 135 kDa polypeptide|DNA-directed RNA polymerase I 135kDa polypeptide|DNA-directed RNA polymerase I subunit RPA2|RNA polymerase 1-2, 128 kDa subunit|RNA polymerase I subunit 2
|
| Swissprots |
Q3UMX7 P70700
|
| Accessions |
EDL28227 P70700 AK052672 AK083732 AK143501 BAE25401 AK144616 BAE25971 AK156712 AK197463 BB860575 BC060656 AAH60656 U58280 AAC52850 XM_006499025 XP_006499088 XM_006499026 XP_006499089 XR_374430 NM_009086 NP_033112
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000250}.
|
| Top Pathways |
Purine metabolism, RNA polymerase, Pyrimidine metabolism
|