Gene Symbol | SLC12A1 |
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Entrez Gene | 6557 |
Alt Symbol | BSC1, NKCC2 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 |
Other Description | NKCC2A variant A|Na-K-2Cl cotransporter|bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2|kidney-specific Na-K-Cl symporter|solute carrier family 12 (sodium/potassium/chloride transporters), member 1|solute carrier family 12 member 1 |
Swissprots | E9PDW4 Q13621 A8JYA2 |
Accessions | CAA06478 CAA06479 CAA06480 CAJ46935 CCQ42978 EAW77344 EAW77345 EAW77346 Q13621 AA917702 AB032525 BAA84574 AB032526 BAA84575 AB032527 BAA84576 AK129998 BAC85271 AK295375 BAG58334 AK298275 BAG60536 AK298312 BAG60566 BC040138 AAH40138 BC148651 AAI48652 BC156819 AAI56820 BX647067 BX647484 DA632985 EF559316 ABU69043 U58130 AAB07364 XM_005254605 XP_005254662 XM_005254606 XP_005254663 XM_006720656 XP_006720719 XR_931896 NM_000338 NP_000329 NM_001184832 NP_001171761 |
Function | Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. |
Subcellular Location | Membrane; Multi-pass membrane protein. |
Tissue Specificity | Kidney specific. |
NKCC2 CRISPR/Cas9 KO Plasmid (h) - sc-401707 from Santa Cruz Biotechnology
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NKCC2 HDR Plasmid (h) - sc-401707-HDR from Santa Cruz Biotechnology
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NKCC2 Double Nickase Plasmid (h) - sc-401707-NIC from Santa Cruz Biotechnology
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NKCC2 Double Nickase Plasmid (h2) - sc-401707-NIC-2 from Santa Cruz Biotechnology
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NKCC2 CRISPR Activation Plasmid (h) - sc-401707-ACT from Santa Cruz Biotechnology
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NKCC2 CRISPR Activation Plasmid (h2) - sc-401707-ACT-2 from Santa Cruz Biotechnology
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NKCC2 Lentiviral Activation Particles (h) - sc-401707-LAC from Santa Cruz Biotechnology
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NKCC2 Lentiviral Activation Particles (h2) - sc-401707-LAC-2 from Santa Cruz Biotechnology
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NKCC2 siRNA (h) - sc-42517 from Santa Cruz Biotechnology
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NKCC2 shRNA Plasmid (h) - sc-42517-SH from Santa Cruz Biotechnology
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NKCC2 shRNA (h) Lentiviral Particles - sc-42517-V from Santa Cruz Biotechnology
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NKCC siRNA (h) - sc-43972 from Santa Cruz Biotechnology
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NKCC shRNA Plasmid (h) - sc-43972-SH from Santa Cruz Biotechnology
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NKCC shRNA (h) Lentiviral Particles - sc-43972-V from Santa Cruz Biotechnology
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NKCC2/SLC12A1 RNAi - H00006557-R01 from Novus Biologicals
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MISSION® esiRNA - EHU075201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19403 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19403 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08501 from Sigma-Aldrich
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SLC12A1 siRNA (Human) - CRH4447 from Cohesion Biosciences
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SLC12A1 - MBS8202897 from MyBioSource
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NKCC2 CRISPR/Cas9 KO Plasmid (h2) - sc-401707-KO-2 from Santa Cruz Biotechnology
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NKCC2 HDR Plasmid (h2) - sc-401707-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Slc12a1 (NM_000338.2) - SHH408300 from Creative biogene
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shRNA set against Human SLC12A1(NM_000338.2) - SHR228066 from Creative biogene
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