Gene Symbol | ANKRD17 |
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Entrez Gene | 26057 |
Alt Symbol | GTAR, MASK2, NY-BR-16 |
Species | Human |
Gene Type | protein-coding |
Description | ankyrin repeat domain 17 |
Other Description | ankyrin repeat domain-containing protein 17|gene trap ankyrin repeat protein|serologically defined breast cancer antigen NY-BR-16 |
Swissprots | Q6PKA2 Q9H6J9 Q6PJ85 Q8NDR5 G5E964 Q96I86 Q86XI3 O75179 E7EUV3 Q9H288 Q6PK85 |
Accessions | EAX05654 EAX05655 EAX05656 EAX05657 EAX05658 O75179 AB014597 BAA31672 AF308285 AAG48253 AI680274 AK025859 BAB15260 AK055209 AK096518 BAG53312 AK299046 BAG61120 AK300302 BAG62055 AK307581 AL831903 CAD38571 AL833287 BC004173 AAH04173 BC004891 BC007747 AAH07747 BC009043 BC019963 AAH19963 BC029935 BC043394 AAH43394 BC146382 AAI46383 BU608983 BU687888 BX648035 CA310544 CD690889 DC335632 XM_005265667 XP_005265724 XM_005265671 XP_005265728 XM_005265672 XP_005265729 XM_005265673 XP_005265730 NM_001286771 NP_001273700 NM_032217 NP_115593 NM_198889 NP_942592 |
Function | Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). {ECO:0000250|UniProtKB:Q99NH0, ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336, ECO:0000269|PubMed:23711367}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:22328336}. Nucleus {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984, ECO:0000269|PubMed:22328336}. Note=Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:17276651, ECO:0000269|PubMed:19150984}. |
ANKRD17 CRISPR/Cas9 KO Plasmid (h) - sc-409873 from Santa Cruz Biotechnology
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ANKRD17 HDR Plasmid (h) - sc-409873-HDR from Santa Cruz Biotechnology
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ANKRD17 Double Nickase Plasmid (h) - sc-409873-NIC from Santa Cruz Biotechnology
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ANKRD17 Double Nickase Plasmid (h2) - sc-409873-NIC-2 from Santa Cruz Biotechnology
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ANKRD17 CRISPR Activation Plasmid (h) - sc-409873-ACT from Santa Cruz Biotechnology
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ANKRD17 CRISPR Activation Plasmid (h2) - sc-409873-ACT-2 from Santa Cruz Biotechnology
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ANKRD17 Lentiviral Activation Particles (h) - sc-409873-LAC from Santa Cruz Biotechnology
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ANKRD17 Lentiviral Activation Particles (h2) - sc-409873-LAC-2 from Santa Cruz Biotechnology
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ANKRD17 siRNA (h) - sc-89052 from Santa Cruz Biotechnology
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ANKRD17 shRNA Plasmid (h) - sc-89052-SH from Santa Cruz Biotechnology
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ANKRD17 shRNA (h) Lentiviral Particles - sc-89052-V from Santa Cruz Biotechnology
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ANKRD17 RNAi - H00026057-R01 from Novus Biologicals
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ANKRD17 RNAi - H00026057-R02 from Novus Biologicals
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MISSION® esiRNA - EHU074141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3180 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3180 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09681 from Sigma-Aldrich
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ANKRD17 siRNA (Human) - CRH8686 from Cohesion Biosciences
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ANKRD17 - MBS8205934 from MyBioSource
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shRNA set against Human Ankrd17 (NM_198889.1) - SHH236636 from Creative biogene
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shRNA set against Human ANKRD17(NM_032217.3) - SHG059671 from Creative biogene
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shRNA set against Human ANKRD17(NM_198889.1) - SHG059689 from Creative biogene
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Human ANKRD17 siRNA - orb269188 from Biorbyt
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ANKRD17 shRNA Plasmid (Human) - CHH8686 from Cohesion Biosciences
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ANKRD17 miRNA 3'UTR clone - MiUTR1H-00383 from Creative biogene
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