| Gene Symbol | E2F5 |
|---|---|
| Entrez Gene | 1875 |
| Alt Symbol | E2F-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | E2F transcription factor 5, p130-binding |
| Other Description | transcription factor E2F5 |
| Swissprots | Q16601 Q15329 Q92756 E9PBN9 |
| Accessions | AAN46737 CBJ05776 CBJ21228 EAW87122 EAW87123 Q15329 AB209185 BAD92422 AI740797 BC156210 AAI56211 BC172475 AAI72475 BM919591 BP224536 CN312917 DB534924 U15642 AAC50120 U31556 AAB00179 X86097 CAA60051 Z78409 CAB01634 XM_006716434 XP_006716497 XM_011517477 XP_011515779 NM_001083588 NP_001077057 NM_001083589 NP_001077058 NM_001951 NP_001942 |
| Function | Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14}. |
| Subcellular Location | Nucleus. |
| Top Pathways | Cell cycle, TGF-beta signaling pathway |