E2F5
| Gene Symbol | E2F5 |
|---|---|
| Entrez Gene | 1875 |
| Alt Symbol | E2F-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | E2F transcription factor 5, p130-binding |
| Other Description | transcription factor E2F5 |
| Swissprots | Q16601 Q15329 Q92756 E9PBN9 |
| Accessions | AAN46737 CBJ05776 CBJ21228 EAW87122 EAW87123 Q15329 AB209185 BAD92422 AI740797 BC156210 AAI56211 BC172475 AAI72475 BM919591 BP224536 CN312917 DB534924 U15642 AAC50120 U31556 AAB00179 X86097 CAA60051 Z78409 CAB01634 XM_006716434 XP_006716497 XM_011517477 XP_011515779 NM_001083588 NP_001077057 NM_001083589 NP_001077058 NM_001951 NP_001942 |
| Function | Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor- initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14}. |
| Subcellular Location | Nucleus. |
| Top Pathways | Cell cycle, TGF-beta signaling pathway |
E2F-5 CRISPR/Cas9 KO Plasmid (h) - sc-401915 from Santa Cruz Biotechnology
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E2F-5 HDR Plasmid (h) - sc-401915-HDR from Santa Cruz Biotechnology
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E2F-5 Double Nickase Plasmid (h) - sc-401915-NIC from Santa Cruz Biotechnology
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E2F-5 Double Nickase Plasmid (h2) - sc-401915-NIC-2 from Santa Cruz Biotechnology
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E2F-5 CRISPR Activation Plasmid (h) - sc-401915-ACT from Santa Cruz Biotechnology
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E2F-5 CRISPR Activation Plasmid (h2) - sc-401915-ACT-2 from Santa Cruz Biotechnology
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E2F-5 Lentiviral Activation Particles (h) - sc-401915-LAC from Santa Cruz Biotechnology
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E2F-5 Lentiviral Activation Particles (h2) - sc-401915-LAC-2 from Santa Cruz Biotechnology
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E2F-5 siRNA (h) - sc-35250 from Santa Cruz Biotechnology
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E2F-5 shRNA Plasmid (h) - sc-35250-SH from Santa Cruz Biotechnology
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E2F-5 shRNA (h) Lentiviral Particles - sc-35250-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU037811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7607 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7607 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05827 from Sigma-Aldrich
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E2F5 siRNA (Human) - CRH1310 from Cohesion Biosciences
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E2F5 RNAi - H00001875-R01 from Novus Biologicals
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E2F5 - MBS8230354 from MyBioSource
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shRNA set against Human E2F5 (NM_001951.3) - SHH282529 from Creative biogene
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shRNA set against Human E2F5(NM_001083589.1) - SHH021899 from Creative biogene
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shRNA set against Human E2F5(NM_001083588.1) - SHH021900 from Creative biogene
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shRNA set against Human E2F5(NM_001083589.1) - SHH021901 from Creative biogene
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shRNA set against Human E2F5(NM_001083588.1) - SHH021902 from Creative biogene
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shRNA set against Human E2F5(NM_001083589.1) - SHH021903 from Creative biogene
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shRNA set against Human E2F5(NM_001083588.1) - SHH021904 from Creative biogene
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