| Gene Symbol |
YEATS4
|
| Entrez Gene |
8089
|
| Alt Symbol |
4930573H17Rik, B230215M10Rik, GAS41, NUBI-1, YAF9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
YEATS domain containing 4
|
| Other Description |
NuMA binding protein 1|YEATS domain-containing protein 4|glioma-amplified sequence 41|glioma-amplified sequence-41|nuBI1|nuMA-binding protein 1
|
| Swissprots |
O95619 Q9NQD0
|
| Accessions |
EAW97223 EAW97224 O95619 AJ245746 CAC01935 AK001413 BAA91678 BC000994 AAH00994 CA775118 CK820576 DN915967 EU446926 ABZ92455 U61384 AAD12188 XR_944742 NM_001300950 NP_001287879 NM_006530 NP_006521
|
| Function |
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. {ECO:0000269|PubMed:14966270}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00376, ECO:0000269|PubMed:10913114}.
|
| Tissue Specificity |
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269|PubMed:10913114}.
|