| Gene Symbol |
TUP1
|
| Entrez Gene |
850445
|
| Alt Symbol |
AAR1, AER2, AMM1, CRT4, CYC9, FLK1, ROX4, SFL2, UMR7
|
| Species |
Yeast
|
| Gene Type |
protein-coding
|
| Description |
chromatin-silencing transcriptional regulator TUP1
|
| Other Description |
-
|
| Swissprots |
P17995 P18323 D6VR85 P16649
|
| Accessions |
DAA07554 P16649 NM_001178790 NP_010007
|
| Function |
Acts as component of the CYC8-TUP1 corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes including heme-regulated and catabolite repressed genes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors, like MATALPHA2, MIG1, RFX1 and SKO1. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex. {ECO:0000269|PubMed:10722672, ECO:0000269|PubMed:11069890, ECO:0000269|PubMed:11172717, ECO:0000269|PubMed:11230135, ECO:0000269|PubMed:11784848, ECO:0000269|PubMed:14665463, ECO:0000269|PubMed:2247069}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14562095}.
|
| Top Pathways |
Cell cycle - yeast
|