LIPA

Gene Symbol LIPA
Entrez Gene 3988
Alt Symbol CESD, LAL
Species Human
Gene Type protein-coding
Description lipase A, lysosomal acid, cholesterol esterase
Other Description acid cholesteryl ester hydrolase|cholesterol ester hydrolase|cholesteryl esterase|lysosomal acid lipase|lysosomal acid lipase/cholesteryl ester hydrolase|sterol esterase
Swissprots Q5T074 B2RBH5 Q96EJ0 Q53H21 D3DR29 Q16529 Q5T771 P38571
Accessions AAB60327 EAW50140 EAW50141 EAW50142 P38571 AK091558 BAG52380 AK096406 BAG53281 AK125193 BAC86078 AK130882 AK222760 BAD96480 AK290241 BAF82930 AK293491 BAG56978 AK297079 BAG59596 AK314665 BAG37222 AU135835 BC012287 AAH12287 CA435432 DA275550 DA394611 DA466221 HQ447241 ADQ31728 HY150944 M74775 AAA59519 S68069 AAB29185 U08464 AAB60328 X76488 CAA54026 Z31690 CAA83495 NM_000235 NP_000226 NM_001127605 NP_001121077 NM_001288979 NP_001275908 NR_110233
Function Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Subcellular Location Lysosome.
Top Pathways Lysosome, Steroid biosynthesis

LAL CRISPR/Cas9 KO Plasmid (h) - sc-402284 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAL HDR Plasmid (h) - sc-402284-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAL Double Nickase Plasmid (h) - sc-402284-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAL Double Nickase Plasmid (h2) - sc-402284-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAL CRISPR Activation Plasmid (h) - sc-402284-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAL CRISPR Activation Plasmid (h2) - sc-402284-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAL Lentiviral Activation Particles (h) - sc-402284-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAL Lentiviral Activation Particles (h2) - sc-402284-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LAL siRNA (h) - sc-72119 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LAL shRNA Plasmid (h) - sc-72119-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LAL shRNA (h) Lentiviral Particles - sc-72119-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU158021 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11742 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11742 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

LIPA siRNA (Human) - CRH2700 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LIPA (NM_000235.2) - SHH330631 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human LIPA(NM_000235.2) - SHH150833 from Creative biogene

Category siRNA
Species Reactivities Human

Human LIPA siRNA - orb263202 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LIPA shRNA Plasmid (Human) - CHH2700 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LIPA miRNA 3'UTR clone - MiUTR1H-05696 from Creative biogene

Species Reactivities Human

LIPA miRNA 3'UTR clone - MiUTR3H-12926 from Creative biogene

Species Reactivities Human
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