| Gene Symbol | CSF3R |
|---|---|
| Entrez Gene | 1441 |
| Alt Symbol | CD114, GCSFR |
| Species | Human |
| Gene Type | protein-coding |
| Description | colony stimulating factor 3 receptor (granulocyte) |
| Other Description | CD114 antigen|G-CSF receptor|G-CSF-R|granulocyte colony-stimulating factor receptor |
| Swissprots | Q99062 |
| Accessions | AAB20660 AAB34956 AAD14994 AAN05790 EAX07354 EAX07355 EAX07356 EAX07357 EAX07358 Q99062 AB209656 BAD92893 AK307242 BC040954 BC053585 AAH53585 BI912247 BU681211 BX370109 DA858302 DQ424902 ABD83667 M59818 AAA63176 M59819 AAA63177 M59820 AAA63178 X55720 CAA39252 X55721 CAA39253 XM_005270493 XP_005270550 XM_011540748 XP_011539050 XM_011540749 XP_011539051 XM_011540750 XP_011539052 NM_000760 NP_000751 NM_156039 NP_724781 NM_172313 NP_758519 NM_156038 |
| Function | Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. {ECO:0000269|PubMed:7514305}. |
| Subcellular Location | Isoform 2: Secreted {ECO:0000305}. |
| Tissue Specificity | One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway |