Gene Symbol | CSF3R |
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Entrez Gene | 1441 |
Alt Symbol | CD114, GCSFR |
Species | Human |
Gene Type | protein-coding |
Description | colony stimulating factor 3 receptor (granulocyte) |
Other Description | CD114 antigen|G-CSF receptor|G-CSF-R|granulocyte colony-stimulating factor receptor |
Swissprots | Q99062 |
Accessions | AAB20660 AAB34956 AAD14994 AAN05790 EAX07354 EAX07355 EAX07356 EAX07357 EAX07358 Q99062 AB209656 BAD92893 AK307242 BC040954 BC053585 AAH53585 BI912247 BU681211 BX370109 DA858302 DQ424902 ABD83667 M59818 AAA63176 M59819 AAA63177 M59820 AAA63178 X55720 CAA39252 X55721 CAA39253 XM_005270493 XP_005270550 XM_011540748 XP_011539050 XM_011540749 XP_011539051 XM_011540750 XP_011539052 NM_000760 NP_000751 NM_156039 NP_724781 NM_172313 NP_758519 NM_156038 |
Function | Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. {ECO:0000269|PubMed:7514305}. |
Subcellular Location | Isoform 2: Secreted {ECO:0000305}. |
Tissue Specificity | One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, PI3K-Akt signaling pathway |
Active human GCSF Receptor protein fragment - ab168697 from Abcam
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GCSF Receptor protein (Fc Chimera Active) - ab83994 from Abcam
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Human GCSF Receptor protein fragment - ab158213 from Abcam
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CSF3R / CD114 Antibody Blocking Peptide - LS-E9925 from LifeSpan Bioscience
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CSF3R / CD114 Antibody Blocking Peptide - LS-E27966 from LifeSpan Bioscience
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G-CSF R/CD114 Partial Recombinant Protein - H00001441-Q01 from Novus Biologicals
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Recombinant Human G-CSF R/CD114 Protein - H00001441-G01 from Novus Biologicals
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CSF3R-Antibody-Center-Blocking-Peptide - BP9075c from Abgent, a WuXi AppTec company
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Recombinant Human G-CSF R/CD114 - 381-GR-050 from R&D Systems
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Recombinant Human G-CSF R/CD114, CF - 381-GR-050/CF from R&D Systems
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Recombinant human Granulocyte colony-stimulating factor receptor (OPCA00891) - OPCA00891 from Aviva Systems Biology
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Human CD114 protein - orb138343 from Biorbyt
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Human GCSFR Protein - abx066036 from Abbexa
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Human GCSFR Protein - abx066037 from Abbexa
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CD114 / CSF3R - H00001441-G01 from Acris Antibodies
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CD114 / CSF3R - H00001441-Q01-10 from Acris Antibodies
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CD114 / CSF3R - H00001441-Q01-25 from Acris Antibodies
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Colony Stimulating Factor Receptor Granulocyte - 20-7743 from ARP American Research Products
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Colony Stimulating Factor Receptor Granulocyte - 20-7744 from ARP American Research Products
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CSF3R Peptide - 43-097P from ProSci
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GCSFR Recombinant Protein - 96-342 from ProSci
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GCSFR Recombinant Protein - 96-343 from ProSci
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G-CSF-R fusion protein - Ag5848 from Proteintech Group
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G-CSF-R fusion protein - Ag5992 from Proteintech Group
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Recombinant Human CSF3R, His tagged - CSF3R-5175H from Creative Biomart
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