| Gene Symbol | NTHL1 |
|---|---|
| Entrez Gene | 4913 |
| Alt Symbol | NTH1, OCTS3, hNTH1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nth endonuclease III-like 1 (E. coli) |
| Other Description | DNA glycoslyase/AP lyase|bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase|endonuclease III-like protein 1 |
| Swissprots | Q9BPX2 Q99794 Q99566 Q1MVR1 P78549 |
| Accessions | AAC34209 AAM11786 ADP92214 ADP92215 ADP92216 ADP92217 ADP92218 ADP92219 ADP92220 ADP92221 ADP92222 ADP92223 ADP92224 ADP92225 ADP92226 ADP92227 ADP92228 ADP92229 ADP92230 ADP92231 ADP92232 ADP92233 ADP92234 ADP92235 ADP92236 ADP92237 ADP92238 ADP92239 ADP92240 ADP92241 ADP92242 ADP92243 ADP92244 ADP92245 ADP92246 ADP92247 ADP92248 ADP92249 ADP92250 ADP92251 ADP92252 ADP92253 BAA32695 EAW85562 P78549 AB001575 BAA19413 BC000391 AAH00391 BC003014 AAH03014 U79718 AAB41534 U81285 AAC51136 Y09687 CAA70865 XM_011522505 XP_011520807 NM_002528 NP_002519 |
| Function | Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. {ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:11328882, ECO:0000269|PubMed:11380260, ECO:0000269|PubMed:11695910, ECO:0000269|PubMed:12140329, ECO:0000269|PubMed:12144783, ECO:0000269|PubMed:12519758, ECO:0000269|PubMed:14734554, ECO:0000269|PubMed:1553383 |
| Subcellular Location | Nucleus. Mitochondrion. |
| Tissue Specificity | Widely expressed with highest levels in heart and lowest levels in lung and liver. {ECO:0000269|PubMed:8990169, ECO:0000269|PubMed:9831664}. |
| Top Pathways | Base excision repair |