NTHL1

Gene Symbol NTHL1
Entrez Gene 4913
Alt Symbol NTH1, OCTS3, hNTH1
Species Human
Gene Type protein-coding
Description nth endonuclease III-like 1 (E. coli)
Other Description DNA glycoslyase/AP lyase|bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase|endonuclease III-like protein 1
Swissprots Q9BPX2 Q99794 Q99566 Q1MVR1 P78549
Accessions AAC34209 AAM11786 ADP92214 ADP92215 ADP92216 ADP92217 ADP92218 ADP92219 ADP92220 ADP92221 ADP92222 ADP92223 ADP92224 ADP92225 ADP92226 ADP92227 ADP92228 ADP92229 ADP92230 ADP92231 ADP92232 ADP92233 ADP92234 ADP92235 ADP92236 ADP92237 ADP92238 ADP92239 ADP92240 ADP92241 ADP92242 ADP92243 ADP92244 ADP92245 ADP92246 ADP92247 ADP92248 ADP92249 ADP92250 ADP92251 ADP92252 ADP92253 BAA32695 EAW85562 P78549 AB001575 BAA19413 BC000391 AAH00391 BC003014 AAH03014 U79718 AAB41534 U81285 AAC51136 Y09687 CAA70865 XM_011522505 XP_011520807 NM_002528 NP_002519
Function Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. {ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:11328882, ECO:0000269|PubMed:11380260, ECO:0000269|PubMed:11695910, ECO:0000269|PubMed:12140329, ECO:0000269|PubMed:12144783, ECO:0000269|PubMed:12519758, ECO:0000269|PubMed:14734554, ECO:0000269|PubMed:1553383
Subcellular Location Nucleus. Mitochondrion.
Tissue Specificity Widely expressed with highest levels in heart and lowest levels in lung and liver. {ECO:0000269|PubMed:8990169, ECO:0000269|PubMed:9831664}.
Top Pathways Base excision repair

NTH1 CRISPR/Cas9 KO Plasmid (h) - sc-409143 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTH1 HDR Plasmid (h) - sc-409143-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTH1 Double Nickase Plasmid (h) - sc-409143-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTH1 Double Nickase Plasmid (h2) - sc-409143-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTH1 CRISPR Activation Plasmid (h) - sc-409143-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTH1 CRISPR Activation Plasmid (h2) - sc-409143-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTH1 Lentiviral Activation Particles (h) - sc-409143-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTH1 Lentiviral Activation Particles (h2) - sc-409143-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NTH1 siRNA (h) - sc-38133 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NTH1 shRNA Plasmid (h) - sc-38133-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NTH1 shRNA (h) Lentiviral Particles - sc-38133-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NTH1 RNAi - H00004913-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU154471 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15560 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15560 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NTHL1 siRNA (Human) - CRH3264 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NTHL1 (NM_002528.5) - SHH355676 from Creative biogene

Category siRNA
Species Reactivities Human

Human NTHL1 siRNA - orb263766 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NTHL1 shRNA Plasmid (Human) - CHH3264 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NTHL1 miRNA 3'UTR clone - MiUTR1H-06943 from Creative biogene

Species Reactivities Human
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