| Gene Symbol | PRKACA |
|---|---|
| Entrez Gene | 5566 |
| Alt Symbol | PKACA, PPNAD4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase, cAMP-dependent, catalytic, alpha |
| Other Description | PKA C-alpha|cAMP-dependent protein kinase catalytic subunit alpha|protein kinase A catalytic subunit |
| Swissprots | Q32P54 Q9NRH9 Q9H2Y0 Q9NRB4 P17612 |
| Accessions | ABG25918 EAW84397 EAW84398 EAW84399 EAW84400 P17612 AF208004 AAG35720 AF224718 AAF75622 AF239744 AAF76426 AK093803 AK131561 AK290147 BAF82836 AK292284 BAF84973 AK301264 BAH13444 BC039846 AAH39846 BC108259 AAI08260 BU543573 M80335 AAA60094 X07767 CAA30597 NM_001304349 NP_001291278 NM_002730 NP_002721 NM_207518 NP_997401 |
| Function | Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B- alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasi |
| Subcellular Location | Cytoplasm. Cell membrane. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Isoform 1 is ubiquitous. Isoform 2 is sperm- specific and is enriched in pachytene spermatocytes but is not detected in round spermatids. {ECO:0000269|PubMed:10906071, ECO:0000269|PubMed:21812984}. |
| Top Pathways | Calcium signaling pathway, Ovarian steroidogenesis, MAPK signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes |